Evidence map›Paper›PMID 31975687›Full record

ArticleeLife2020

Recruitment of mRNAs to P granules by condensation with intrinsically-disordered proteins.

Chih-Yung S Lee, Andrea Putnam, Tu Lu, ShuaiXin He, John Paul T Ouyang, Geraldine Seydoux

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 131 citations in OpenAlex.

  1. Article
  2. bioRxiv : the preprint server for biology · 2026
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  18. A mechanism for MEX-5-driven disassembly of PGL-3/RNA condensates in vitro.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  19. Article
  20. Landscape and regulation of mRNA translation in the earlybioRxiv : the preprint server for biology · 2025
    Article

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Chih-Yung S LeeHHMI and Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, United States.
Andrea PutnamHHMI and Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, United States.ORCID 0000-0001-7985-142X
Tu LuHHMI and Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, United States.ORCID 0000-0002-5697-300X
ShuaiXin HeHHMI and Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, United States.
John Paul T OuyangHHMI and Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, United States.ORCID 0000-0003-2030-432X
Geraldine SeydouxHHMI and Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, United States.ORCID 0000-0001-8257-0493
Johns Hopkins University · US

Funding

BIOCHEMISTRY, CELLULAR AND MOLECULAR BIOLOGY PROGRAMT32GM007445 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI GREEN, RACHEL · 1985 to 2021
$24.1M
Murine Mutagenesis CoreP30NS050274 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KOLODKIN, ALEX L · 2005 to 2020
$10.9M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Regulation of Germ Cell Fate During EmbryogenesisR37HD037047 · NICHD · JOHNS HOPKINS UNIVERSITY · PI SEYDOUX, GERALDINE CATHERINE JOELLE · 2016 to 2025
$3.8M
Zeiss LSM780 Confocal Microscope for a Core FacilityS10OD016374 · OD · JOHNS HOPKINS UNIVERSITY · PI KUO, SCOT CHARLES · 2013 to 2013
$584k
LSM880 Laser-scanning Microscope with Airyscan ModuleS10OD023548 · OD · JOHNS HOPKINS UNIVERSITY · PI KUO, SCOT CHARLES · 2018 to 2018
$439k
NICHD NIH HHS R37 HD037047NIGMS NIH HHS T32 GM007445NIH HHS P40 OD010440NIH HHS S10 OD016374NIH HHS S10 OD023548NINDS NIH HHS P30 NS050274
6 · The paper itself

Abstract

RNA granules are protein/RNA condensates. How specific mRNAs are recruited to cytoplasmic RNA granules is not known. Here, we characterize the transcriptome and assembly of P granules, RNA granules in the

Indexed as

AnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCytoplasmic GranulesGerm CellsImmunoprecipitationIntrinsically Disordered ProteinsProtein BindingProtein BiosynthesisRNA, MessengerCaenorhabditis elegans ProteinsIntrinsically Disordered ProteinsRNA, MessengerC. eleganscell biologydevelopmental biologygerm granulesgerm lineintrinsically-disordered proteinsMEG-3phase transitionRNA granules

Identifiers

PMID31975687
PMCPMC7007223
OpenAlexW3003073247

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.