ArticleJournal of biomedical optics2020
Investigation of light delivery geometries for photoacoustic applications using Monte Carlo simulations with multiple wavelengths, tissue types, and species characteristics.
Article in Journal of biomedical optics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Monte Carlo-Based Optimization of Multi-Source Illumination for Photoacoustic Signal Generation in Human Gray-Matter Vessels.Journal of biophotonics · 2026Article
- Depth-dependent fluence compensation withoutJournal of biomedical optics · 2025Article
- Multi-wavelength imaging photoplethysmography for non-invasive and non-contact assessment of burn severity.Scientific reports · 2025Article
- Ultrasound-guided photoacoustic image annotation toolkit in MATLAB (PHANTOM) for preclinical applications.Photoacoustics · 2025Article
- Dual-Scan Photoacoustic Tomography for the Imaging of Vascular Structure on Foot.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2023Article
- Ultrasound-guided Photoacoustic image Annotation Toolkit in MATLAB (PHANTOM) for preclinical applications.bioRxiv : the preprint server for biology · 2023Article
- Whole-Body Photoacoustic Imaging Techniques for Preclinical Small Animal Studies.Sensors (Basel, Switzerland) · 2022Review
- SIMPA: an open-source toolkit for simulation and image processing for photonics and acoustics.Journal of biomedical optics · 2022Article
- Towards Transabdominal Functional Photoacoustic Imaging of the Placenta: Improvement in Imaging Depth Through Optimization of Light Delivery.Annals of biomedical engineering · 2021Article
- 3D Monte Carlo simulation of light distribution in mouse brain in quantitative photoacoustic computed tomography.Quantitative imaging in medicine and surgery · 2021Article
- Multiangle Long-Axis Lateral Illumination Photoacoustic Imaging Using Linear Array Transducer.Sensors (Basel, Switzerland) · 2020Article
- Optimizing Irradiation Geometry in LED-Based Photoacoustic Imaging with 3D Printed Flexible and Modular Light Delivery System.Sensors (Basel, Switzerland) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Combined ultrasound and photoacoustic imaging systems are being developed for biomedical and clinical applications. One common probe configuration is to use a linear transducer array with external light delivery to produce coregistered ultrasound and photoacoustic images. The diagnostic capability of these systems is dependent on the effectiveness of light delivery to the imaging target. We use Monte Carlo modeling to investigate the optimal design geometry of an integrated probe. Simulations are conducted with multiple tissue compositions and wavelengths. The effect of a skin layer with the thickness of a mouse or a human is also considered. The model was validated using a tissue-mimicking gelatin phantom and corresponding Monte Carlo simulations. The optimal illumination angle is shallower with human skin thickness, whereas intermediate angles are ideal with mouse skin thickness. The effect of skin thickness explains differences in the results of prior work. The simulations also indicate that even with identical hardware and imaging parameters, light delivery will be up to 3 × smaller in humans than in mice, due to the increased scattering from thicker skin. Our findings have clear implications for the many researchers using mice to test and develop imaging methods for clinical translation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.