ArticleAnnals of neurology2020
Mendelian Randomization Study of Obesity and Cerebrovascular Disease.
Article in Annals of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 6 of them syntheses that pooled it.
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Who cites it
85 citing papers in PubMed, 6 syntheses or guidelines pooled it, 151 citations in OpenAlex.
- Meta-analysis of Early Risk Factors Associated with Cerebrovascular Diseases.Current neurovascular research · 2026Pooled it
- Association between early age body mass index and the risk of adulthood cardiovascular diseases: a systematic review and meta-analysis.International journal of obesity (2005) · 2025Pooled it
- Risk Factors for Intracerebral Hemorrhage: Genome-Wide Association Study and Mendelian Randomization Analyses.Stroke · 2024Pooled it
- Comparative outcomes of obese and non-obese patients with lumbar disc herniation receiving full endoscopic transforaminal discectomy: a systematic review and meta-analysis.BMC musculoskeletal disorders · 2024Pooled it
- Appraising the Causal Role of Risk Factors in Coronary Artery Disease and Stroke: A Systematic Review of Mendelian Randomization Studies.Journal of the American Heart Association · 2023Pooled it
- Causal associations of insulin resistance with coronary artery disease and ischemic stroke: a Mendelian randomization analysis.BMJ open diabetes research & care · 2020Pooled it
- Microbiota-Gut-Brain Axis Mechanisms in Cognitive Impairment Associated with Central Obesity.Current obesity reports · 2026Review
- Investigating the causal associations between neuroticism, schizophrenia, and cardiovascular diseases using Mendelian randomization.European archives of psychiatry and clinical neuroscience · 2026Article
- Physical Activity Behavior and Acute Myocardial Infarction, Stroke, and Sepsis Outcomes in Brazil: Insights from Targeted Eigenvector Centrality Networks.International journal of environmental research and public health · 2026Article
- Deciphering the causal influence of BMI and related metabolic, inflammatory, and cardiovascular factors on brain structure: a Mendelian Randomization Study.Molecular psychiatry · 2026Article
- Genetics of intracerebral hemorrhage.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Review
- Genetically Simulated GLP-1 Receptor Agonism and Cerebral Small Vessel Disease.Neurology. Genetics · 2026Article
- Burden of Intracerebral Hemorrhage in Asia from 1990 to 2030: A Population-Based Study.Neuroepidemiology · 2026Article
- Association of cholesterol, high-density lipoprotein, and glucose index and its modified indices with the risk of stroke: insights from CHARLS.BMC neurology · 2025Article
- Joint association of body mass index, abdominal obesity, and triglyceride-glucose index with stroke risk: insights from the China health and retirement longitudinal study.BMC neurology · 2025Article
- Evaluation of causal relationships between genetic liability to inflammatory bowel disease and autism spectrum disorder by Mendelian randomization analysis.Dialogues in clinical neuroscience · 2025Article
- Relationship between childhood obesity and cardiovascular and cerebrovascular diseases: a study based on the combination of multiple databases.BMC public health · 2025Article
- Observational
- Impact of abdominal obesity indices on all-cause and cardiovascular mortality in individuals with pre-diabetes and diabetes: insights from a prospective cohort study.BMC public health · 2025Article
- Interplay of Acquired Risk Factors, Age, and Genetic Predisposition in Incident Stroke: A Prospective Cohort Study.Journal of the American Heart Association · 2025Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors at 8 institutions in 4 countries.
Funding
Abstract
objectiveTo systematically investigate causal relationships between obesity and cerebrovascular disease and the extent to which hypertension and hyperglycemia mediate the effect of obesity on cerebrovascular disease.
methodsWe used summary statistics from genome-wide association studies for body mass index (BMI), waist-to-hip ratio (WHR), and multiple cerebrovascular disease phenotypes. We explored causal associations with 2-sample Mendelian randomization (MR) accounting for genetic covariation between BMI and WHR, and we assessed what proportion of the association between obesity and cerebrovascular disease was mediated by systolic blood pressure (SBP) and blood glucose levels, respectively.
resultsGenetic predisposition to higher BMI did not increase the risk of cerebrovascular disease. In contrast, for each 10% increase in WHR there was a 75% increase (95% confidence interval [CI] = 44-113%) in risk for large artery ischemic stroke, a 57% (95% CI = 29-91%) increase in risk for small vessel ischemic stroke, a 197% increase (95% CI = 59-457%) in risk of intracerebral hemorrhage, and an increase in white matter hyperintensity volume (β = 0.11, 95% CI = 0.01-0.21). These WHR associations persisted after adjusting for genetic determinants of BMI. Approximately one-tenth of the observed effect of WHR was mediated by SBP for ischemic stroke (proportion mediated: 12%, 95% CI = 4-20%), but no evidence of mediation was found for average blood glucose.
interpretationAbdominal adiposity may trigger causal pathological processes, partially independent from blood pressure and totally independent from glucose levels, that lead to cerebrovascular disease. Potential targets of these pathological processes could represent novel therapeutic opportunities for stroke. ANN NEUROL 2020;87:516-524.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.