Evidence map›Paper›PMID 31975494›Full record

ArticleEuropean journal of heart failure2020

Biventricular pacemaker therapy improves exercise capacity in patients with non-obstructive hypertrophic cardiomyopathy via augmented diastolic filling on exercise.

Ibrar Ahmed, Brodie L Loudon, Khalid Abozguia, Donnie Cameron, Ganesh N Shivu, Thanh T Phan, Abdul Maher, Berthold Stegemann, Anthony Chow, Howard Marshall and 6 more

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of heart failure, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00504647 (Diastolic Ventricular Interaction and the Effects Of Biventricular Pacing in Hypertrophic Cardiomyopathy), which is not on this map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00504647 phase1unknown statusnot on this map

Diastolic Ventricular Interaction and the Effects Of Biventricular Pacing in Hypertrophic Cardiomyopathy

TypeinterventionalSponsorUniversity Hospital BirminghamRan2006 to 2008Enrolled30ConditionsHypertrophic CardiomyopathyArmsBiventricular Pacemaker
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 9 institutions in 4 countries.

Ibrar AhmedDepartment of Cardiovascular Medicine, University of Birmingham, Birmingham, UK.
Brodie L LoudonNorwich Medical School, University of East Anglia, Norwich, UK.
Khalid AbozguiaDepartment of Cardiovascular Medicine, University of Birmingham, Birmingham, UK.
Donnie CameronNorwich Medical School, University of East Anglia, Norwich, UK.
Ganesh N ShivuDepartment of Cardiovascular Medicine, University of Birmingham, Birmingham, UK.
Thanh T PhanDepartment of Cardiovascular Medicine, University of Birmingham, Birmingham, UK.
Abdul MaherDepartment of Cardiovascular Medicine, University of Birmingham, Birmingham, UK.
Berthold StegemannBakken Research Centre, Medtronic Inc., Maastricht, The Netherlands.
Anthony ChowDepartment of Cardiovascular Medicine, Royal Berkshire NHS Foundation Trust, Reading, UK.
Howard MarshallQueen Elizabeth Hospital Birmingham, Welcome Trust Clinical Research Facility, Birmingham, UK.
Peter NightingaleQueen Elizabeth Hospital Birmingham, Welcome Trust Clinical Research Facility, Birmingham, UK.
Francisco LeyvaDepartment of Cardiovascular Medicine, Queen Elizabeth Hospital, Birmingham, UK.
Vassilios S VassiliouNorwich Medical School, University of East Anglia, Norwich, UK.
William J McKennaInstitute of Cardiovascular Science, University College of London, London, UK.
Perry ElliottInstitute of Cardiovascular Science, University College of London, London, UK.
Michael P FrenneauxNorwich Medical School, University of East Anglia, Norwich, UK.
University of East Anglia · GBQueen Elizabeth Hospital Birmingham · GBUniversity of Alabama at Birmingham · USBakken Museum · USRoyal Berkshire NHS Foundation Trust · GBThe London College · GBUniversity College Birmingham · GBUniversity College London · GBUniversity of Birmingham · GB

Funding

British Heart Foundation PG/05/087
6 · The paper itself

Abstract

aimsTreatment options for patients with non-obstructive hypertrophic cardiomyopathy (HCM) are limited. We sought to determine whether biventricular (BiV) pacing improves exercise capacity in HCM patients, and whether this is via augmented diastolic filling. METHODS AND

resultsThirty-one patients with symptomatic non-obstructive HCM were enrolled. Following device implantation, patients underwent detailed assessment of exercise diastolic filling using radionuclide ventriculography in BiV and sham pacing modes. Patients then entered an 8-month crossover study of BiV and sham pacing in random order, to assess the effect on exercise capacity [peak oxygen consumption (VO

conclusionSymptomatic patients with non-obstructive HCM may benefit from BiV pacing via augmentation of diastolic filling on exercise rather than contractile improvement. This may be due to relief of diastolic ventricular interaction. CLINICAL

trial registrationClinicalTrials.gov NCT00504647.

Indexed as

Cardiomyopathy, HypertrophicHeart FailurePacemaker, ArtificialCardiac Pacing, ArtificialCardiac Resynchronization Therapy DevicesCross-Over StudiesDiastoleExercise ToleranceFemaleHumansMaleMiddle AgedQuality of LifeStroke VolumeVentricular Function, LeftBiventricular pacemaker therapyDiastolic ventricular interactionHypertrophic cardiomyopathy

Identifiers

PMID31975494
PMCPMC7540697
OpenAlexW3003047624

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.