Evidence map›Paper›PMID 31975366›Full record

ArticleBritish journal of pharmacology2020

Scorpion toxin inhibits the voltage-gated proton channel using a Zn

Dongfang Tang, Yuqin Yang, Zhen Xiao, Jiahui Xu, Qiuchu Yang, Han Dai, Songping Liang, Cheng Tang, Hao Dong, Zhonghua Liu

Open access · bronzeAbstract read
In one paragraph

Article in British journal of pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Modulators of the Human Voltage-Gated Proton Channel HPharmaceuticals (Basel, Switzerland) · 2025
    Review
  4. Hv1 channel in immune cells and pharmacology.Pharmacological research · 2025
    Review
  5. Fluctuating hydrogen-bond network of the Hv1 ion channel.Computational and structural biotechnology journal · 2025
    Article
  6. Review
  7. Inhibition of the HFrontiers in immunology · 2024
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Dimer interaction in the Hv1 proton channel.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Dongfang TangThe National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, China.
Yuqin YangKuang Yaming Honors School, Nanjing University, Nanjing, China.
Zhen XiaoThe National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, China.
Jiahui XuThe National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, China.
Qiuchu YangThe National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, China.
Han DaiThe National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, China.
Songping LiangThe National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, China.
Cheng TangThe National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, China.
Hao DongKuang Yaming Honors School, Nanjing University, Nanjing, China.ORCID 0000-0001-7280-7506
Zhonghua LiuThe National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, China.
Hunan Normal University · CNNanjing University of Finance and Economics · CN

Funding

National Nature Science Foundation of China 21773115National Nature Science Foundation of China 21833002National Nature Science Foundation of China 31600669Natural Science Foundation of Hunan Province 2018JJ3339Natural Science Foundation of Jiangsu Province BK20190056Research Foundation of the Education Department of Hunan Province 18B015
6 · The paper itself

Abstract

background and purposeBlocking the voltage-gated proton channel H EXPERIMENTAL APPROACH: H KEY

resultsThe scorpion toxin AGAP (anti-tumour analgesic peptide) potently inhibited H CONCLUSION AND IMPLICATIONS: Our results suggest that the Zn

Indexed as

Scorpion VenomsAnalgesicsAnimalsIon Channel GatingProtonsZincAnalgesicsProtonsScorpion VenomsZinc

Identifiers

PMID31975366
PMCPMC7174885
OpenAlexW3002770340

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.