Evidence map›Paper›PMID 31975053›Full record

Trial reportGeroScience2020

Short-term time-restricted feeding is safe and feasible in non-obese healthy midlife and older adults.

Christopher R Martens, Matthew J Rossman, Melissa R Mazzo, Lindsey R Jankowski, Erzsebet E Nagy, Blair A Denman, James J Richey, Sarah A Johnson, Brian P Ziemba, Yang Wang and 3 more

2 registry-linked trialsOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in GeroScience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 116 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
116citing papers in PubMed, 13 pooled it
11.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05124847 nacompletednot on this mapstarted 2021, after this paper: background citation

Time Restricted Eating as a Treatment for Pediatric Obesity

TypeinterventionalSponsorFundación Pública Andaluza para la Investigación de Málaga en Biomedicina y SaludRan2021 to 2023Enrolled30ConditionsInfant Obesity, Hepatic Steatosis, Metabolic Syndrome, Insulin ResistanceArmsStandard Care, Time restricted eating
NCT06429124 narecruitingnot on this mapstarted 2023, after this paper: background citation

Time-Restricted Eating in Alzheimer's Disease : The T.R.E.A.D Trial

TypeinterventionalSponsorSt. Joseph's Hospital and Medical Center, PhoenixRan2023 to 2026Enrolled30ConditionsMild Cognitive Impairment (MCI)ArmsDietary Intervention
3 · Its place in the literature

Who cites it

116 citing papers in PubMed, 13 syntheses or guidelines pooled it, 167 citations in OpenAlex.

  1. Interventions that prolong multidimensional healthspan in humans: a systematic review of randomized controlled trials.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
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  18. A Qualitative Exploration of Facilitators and Barriers to Early Time-Restricted Eating: Insights From a Randomised Controlled Trial.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2025
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56 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Christopher R MartensDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, 80309, USA. cmartens@udel.edu.ORCID 0000-0003-0578-2948
Matthew J RossmanDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, 80309, USA.
Melissa R MazzoDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, 80309, USA.
Lindsey R JankowskiDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, 80309, USA.
Erzsebet E NagyDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, 80309, USA.
Blair A DenmanDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, 80309, USA.
James J RicheyDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, 80309, USA.
Sarah A JohnsonDepartment of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, 80523, USA.
Brian P ZiembaDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, 80309, USA.
Yang WangCenter for Innovative Design & Analysis, University of Colorado School of Public Health, Aurora, CO, 80045, USA.
Courtney M PetersonDepartment of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Michel ChoncholDivision of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Denver, CO, USA.
Douglas R SealsDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, 80309, USA.
University of Colorado Boulder · USColorado School of Public Health · USColorado State University · USUniversity of Alabama at Birmingham · USUniversity of Colorado Anschutz Medical Campus · US

Funding

Why is the prevalence of obesity so high in U.S. Southern States? Regional predictors of BMI and obesity treatment response.P30DK056336 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI James O Hill · 2000 to 2026
$31.9M
University of Colorado Aging Training GrantT32AG000279 · NIA · UNIVERSITY OF COLORADO DENVER · PI Kerrie Moreau · 2001 to 2026
$10.1M
MitoQ Supplementation for Improving Vascular Endothelial Function in Older AdultsF32AG053009 · NIA · UNIVERSITY OF COLORADO · PI ROSSMAN, MATTHEW J · 2016 to 2017
$107k
NIA NIH HHS AG000279NIA NIH HHS AG053009NIA NIH HHS F32 AG053009NIA NIH HHS T32 AG000279NIDDK NIH HHS P30 DK056336
6 · The paper itself

Abstract

Chronic calorie restriction (CR) improves cardiovascular function and several other physiological markers of healthspan. However, CR is impractical in non-obese older humans due to potential loss of lean mass and bone density, poor adherence, and risk of malnutrition. Time-restricted feeding (TRF), which limits the daily feeding period without requiring a reduction in calorie intake, may be a promising alternative healthspan-extending strategy for midlife and older adults; however, there is limited evidence for its feasibility and efficacy in humans. We conducted a randomized, controlled pilot study to assess the safety, tolerability, and overall feasibility of short-term TRF (eating <8 h day

Indexed as

Caloric RestrictionFastingAgedCardiovascular SystemEnergy IntakeFemaleHumansMaleMiddle AgedPilot ProjectsAgingCalorie restrictionHealthspanIntermittent fasting

Identifiers

PMID31975053
PMCPMC7206473
OpenAlexW2992431051

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.