Evidence map›Paper›PMID 31975052›Full record

ArticleGeroScience2020

Blockade of the NLRP3 inflammasome improves metabolic health and lifespan in obese mice.

Diego Cañadas-Lozano, Fabiola Marín-Aguilar, Beatriz Castejón-Vega, Bernhard Ryffel, José M Navarro-Pando, Jesús Ruiz-Cabello, Elísabet Alcocer-Gómez, Pedro Bullón, Mario D Cordero

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Diego Cañadas-LozanoResearch Laboratory, Oral Medicine Department, University of Sevilla, Seville, Spain.
Fabiola Marín-AguilarResearch Laboratory, Oral Medicine Department, University of Sevilla, Seville, Spain.
Beatriz Castejón-VegaResearch Laboratory, Oral Medicine Department, University of Sevilla, Seville, Spain.
Bernhard RyffelLaboratory of Experimental and Molecular Immunology and Neurogenetics (INEM), UMR 7355 CNRS-University of Orleans, Orléans, France.
José M Navarro-PandoCátedra de Reproducción y Genética Humana del Instituto para el Estudio de la Biología de la Reproducción Humana (INEBIR), Universidad Europea del Atlántico (UNEATLANTICO)-Fundación Universitaria Iberoamericana (FUNIBER), Santander, Spain.
Jesús Ruiz-CabelloCIC biomaGUNE, San Sebastian-Donostia, Spain.
Elísabet Alcocer-GómezDepartamento de Psicología Experimental, Facultad de Psicología, Universidad de Sevilla, Seville, Spain.
Pedro BullónResearch Laboratory, Oral Medicine Department, University of Sevilla, Seville, Spain.
Mario D CorderoCátedra de Reproducción y Genética Humana del Instituto para el Estudio de la Biología de la Reproducción Humana (INEBIR), Universidad Europea del Atlántico (UNEATLANTICO)-Fundación Universitaria Iberoamericana (FUNIBER), Santander, Spain. mdcormor@us.es.
Universidad de Sevilla · ESFundación Universitaria Iberoamericana · ESIkerbasque · ESImmunologie et Neurogénétique Expérimentales et Moléculaires · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging is the major risk factor for many metabolic chronic diseases. Several metabolic pathways suffer a progressive impairment during aging including body composition and insulin resistance which are associated to autophagy dysfunction and increased inflammation. Many of these alterations are aggravated by non-healthy lifestyle such as obesity and hypercaloric diet which have been shown to accelerate aging. Here, we show that the deleterious effect of hypercaloric diets is reverted by the NLRP3 inflammasome inhibition. NLRP3 deficiency extends mean lifespan of adult mice fed a high-fat diet. This lifespan extension is accompanied by metabolic health benefits including reduced liver steatosis and cardiac damage, improved glucose and lipid metabolism, and improved protein expression profiles of SIRT-1, mTOR, autophagic flux, and apoptosis. These findings suggest that the suppression of NLRP3 prevented many age-associated changes in metabolism impaired by the effect of hypercaloric diets.

Indexed as

InflammasomesLongevityNLR Family, Pyrin Domain-Containing 3 ProteinAnimalsMiceMice, Inbred C57BLMice, ObeseInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseAgingAutophagyHigh-fat dietLongevityNLRP3 inflammasomeObesity

Identifiers

PMID31975052
PMCPMC7206474
OpenAlexW3002329876

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.