Evidence map›Paper›PMID 31974914›Full record

Trial reportDigestive diseases and sciences2020

Helicobacter pylori Eradication Regressed Gastric Hyperplastic Polyp: A Randomized Controlled Trial.

Su Youn Nam, Sang Won Lee, Seong Woo Jeon, Yong Hwan Kwon, Hyun Seok Lee

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Digestive diseases and sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03065868 (Effect of H. Pylori Eradication on the Fate of H. Pylori-associated Gastric Polyp), which is not on this map. Cited by 10 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03065868 phase4completednot on this map

Effect of H. Pylori Eradication on the Fate of H. Pylori-associated Gastric Polyp (Randomized Controlled Study)

TypeinterventionalSponsorKyungpook National University HospitalRan2015 to 2019Enrolled32ConditionsGastric Polyp, Helicobacter Pylori InfectionArmsH. pylori eradication (Amoxaxillin, Lanston, Clarithromycin)
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. [Evidence-Based Guidelines for the Diagnosis and Treatment ofThe Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2026
    Guideline
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  3. Guideline
  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Su Youn NamDepartment of Gastroenterology, Kyungpook National University Hospital Chilgok, School of Medicine, Kyungpook National University, 807 Hoguk-ro, Buk-gu, Daegu, 41404, Korea. nam20131114@gmail.com.ORCID 0000-0002-5568-7714
Sang Won LeeDepartment of Gastroenterology, Kyungpook National University Hospital Chilgok, School of Medicine, Kyungpook National University, 807 Hoguk-ro, Buk-gu, Daegu, 41404, Korea.
Seong Woo JeonDepartment of Gastroenterology, Kyungpook National University Hospital Chilgok, School of Medicine, Kyungpook National University, 807 Hoguk-ro, Buk-gu, Daegu, 41404, Korea.
Yong Hwan KwonDepartment of Gastroenterology, Kyungpook National University Hospital Chilgok, School of Medicine, Kyungpook National University, 807 Hoguk-ro, Buk-gu, Daegu, 41404, Korea.
Hyun Seok LeeDepartment of Gastroenterology, Kyungpook National University Hospital Chilgok, School of Medicine, Kyungpook National University, 807 Hoguk-ro, Buk-gu, Daegu, 41404, Korea.

Funding

Korean Colleague of Helicobacter and Upper Gastrointestinal Research of Medical Sciences (IR) 2016
6 · The paper itself

Abstract

backgroundHelicobacter pylori infection and hyperplastic polyp are known to have strong connections, but there are not enough randomized controlled trial data.

aimsTo evaluate the effect of H. pylori eradication on gastric hyperplastic polyp.

methodThis is an open-labeled, single-center, randomized controlled trial. Patients with hyperplastic polyp and current infection of H. pylori were randomly assigned to eradication or non-eradication groups. All participants underwent follow-up endoscopy to investigate the regression of gastric polyps. Gastric polyp regression was defined as the disappearance of polyps or a reduction of more than 50% in size.

resultsThirty-two patients were randomized to eradication (n = 17) and non-eradication groups (n = 15). Final included patients were 14 in eradication group and 13 in non-eradication group. All patients showed polyp regression in eradication group, whereas no regression was observed in non-eradication group (P < 0.001). Disappearance of polyp (n = 7) and decrease in size (n = 7) were observed in eradication group. In non-eradication group, no change (n = 5), increase of size (n = 5), and increase of number (n = 3) were observed. Mean regression time was 6.8 months, and disappearance time was 9.8 months. In non-eradication group, hyperglycemia was noted in 50% of progression group but not noted in no change group (P = 0.057).

conclusionsH. pylori eradication induced regression of hyperplastic polyp, and persistent H. pylori infection was related to progression of gastric polyp. CLINICAL

trial registrationClinicalTrials.gov ID: NCT03065868.

Indexed as

Adenomatous PolypsHelicobacter InfectionsHelicobacter pyloriStomach NeoplasmsAmoxicillinAnti-Bacterial AgentsBreath TestsClarithromycinDrug MonitoringEndoscopy, Digestive SystemFemaleHumansLansoprazoleMaleMiddle AgedOutcome Assessment, Health CareAmoxicillinAnti-Bacterial AgentsClarithromycinLansoprazoleProton Pump InhibitorsEradicationGastric polypHelicobacter pyloriRegression

Identifiers

PMID31974914

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.