Evidence map›Paper›PMID 31974913›Full record

ArticleDigestive diseases and sciences2020

Evaluation of Budesonide-Hydroxypropyl-β-Cyclodextrin Inclusion Complex in Thermoreversible Gels for Ulcerative Colitis.

Carolina Martins Lázaro, Carolina C de Oliveira, Alessandra Gambero, Thalita Rocha, Cintia Maria Saia Cereda, Daniele Ribeiro de Araújo, Giovana Radomille Tofoli

Abstract read
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In one paragraph

Article in Digestive diseases and sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Technological evolution of cyclodextrins in the pharmaceutical field.Journal of drug delivery science and technology · 2021
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Carolina Martins LázaroUniversidade São Francisco, Av. São Francisco de Assis 218, Bragança Paulista, São Paulo, 12916-900, Brazil.
Carolina C de OliveiraUniversidade São Francisco, Av. São Francisco de Assis 218, Bragança Paulista, São Paulo, 12916-900, Brazil.
Alessandra GamberoUniversidade Estadual de Campinas, Av. Alexandre Cazelatto 999, Paulínia, 13140-000, São Paulo, Brazil.
Thalita RochaUniversidade São Francisco, Av. São Francisco de Assis 218, Bragança Paulista, São Paulo, 12916-900, Brazil.
Cintia Maria Saia CeredaFaculdade São Leopoldo Mandic, Instituto de Pesquisa São Leopoldo Mandic, Rua José Rocha Junqueira 13, Campinas, São Paulo, 13045-75, Brazil.
Daniele Ribeiro de AraújoUniversidade Federal do ABC, Av. dos Estados 5001, Bl A, Torre 3, Lab 503-3, Santo André, São Paulo, 09210-170, Brazil.
Giovana Radomille TofoliFaculdade São Leopoldo Mandic, Instituto de Pesquisa São Leopoldo Mandic, Rua José Rocha Junqueira 13, Campinas, São Paulo, 13045-75, Brazil. giovana.tofoli@slmandic.edu.br.ORCID 0000-0001-6403-7708
Universidade São Francisco · BRFaculdade São Leopoldo Mandic · BRUniversidade Estadual de Campinas (UNICAMP) · BRUniversidade Federal do ABC · BR

Funding

Fapesp 2014/26200-9
6 · The paper itself

Abstract

backgroundNew formulations for topical treatment of ulcerative colitis with budesonide inclusion complex (BUD

aimsThis study evaluated the efficacy of such novel formulations in a rat model of colitis.

methodsThe PL-BUD

resultsBUD

conclusionNovel budesonide inclusion complex formulations improved microscopic damage and reduced colonic MPO activity and TNF-α levels.

Indexed as

2-Hydroxypropyl-beta-cyclodextrinAnimalsBudesonideColitis, UlcerativeDisease Models, AnimalDrug CombinationsHydrogelsMalePoloxamerRatsRats, Wistar2-Hydroxypropyl-beta-cyclodextrinBudesonideDrug CombinationsHydrogelsPoloxamerBudesonideColitisCyclodextrinsDrug delivery systemsInflammatory bowel diseasePoloxamers

Identifiers

PMID31974913
OpenAlexW3002741943

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.