Evidence map›Paper›PMID 31974733›Full record

ArticleBrain topography2020

Transcranial Alternating Current Stimulation (tACS) as a Tool to Modulate P300 Amplitude in Attention Deficit Hyperactivity Disorder (ADHD): Preliminary Findings.

Isa Dallmer-Zerbe, Fabian Popp, Alexandra Philomena Lam, Alexandra Philipsen, Christoph Siegfried Herrmann

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain topography, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 6 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 6 syntheses or guidelines pooled it, 68 citations in OpenAlex.

  1. Efficacy and safety of tACS in older adults with cognitive impairment: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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  13. Characteristics of auditory event-related potential and prediction ofQuantitative imaging in medicine and surgery · 2026
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  17. Neural Mechanisms Underlying Robust Target Selection in Response to Microstimulation of the Oculomotor System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Isa Dallmer-ZerbeDepartment of Complex Systems, Institute of Computer Science, Czech Academy of Sciences, Prague, Czech Republic.
Fabian PoppExperimental Psychology Lab, Department of Psychology, European Medical School, Cluster for Excellence "Hearing for All", Carl Von Ossietzky University Oldenburg, Ammerländer Heerstr. 114-118, 26129, Oldenburg, Germany.
Alexandra Philomena LamDepartment of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
Alexandra PhilipsenDepartment of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
Christoph Siegfried HerrmannExperimental Psychology Lab, Department of Psychology, European Medical School, Cluster for Excellence "Hearing for All", Carl Von Ossietzky University Oldenburg, Ammerländer Heerstr. 114-118, 26129, Oldenburg, Germany. christoph.herrmann@uni-oldenburg.de.ORCID http://orcid.org/0000-0003-0323-2272
University of Bonn · DECarl von Ossietzky Universität Oldenburg · DECzech Academy of Sciences · CZHearing4all · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Studies examining event-related potentials (ERP) in patients affected by attention deficit/hyperactivity disorder (ADHD) have found considerable evidence of reduced target P300 amplitude across different perceptual modalities. P300 amplitude has been related to attention-driven context comparison and resource allocation processes. Altered P300 amplitude in ADHD can be reasonably assumed to be related to ADHD typical cognitive performance deficits. Transcranial alternating current stimulation (tACS) can increase the amplitude of endogenous brain oscillations. Because ERP components can be viewed as event-related oscillations (EROs), with P300 translating into the delta (0-4 Hz) and theta (4-8 Hz) frequency range, an increase of delta and theta ERO amplitudes by tACS should result in an increase of P300 amplitudes in ADHD patients. In this pilot study, 18 adult ADHD patients (7 female) performed three consecutive blocks of a visual oddball task while the electroencephalogram (EEG) was recorded. Patients received either 20 min of tACS or sham stimulation at a stimulation intensity of 1 mA. Individual stimulation frequency was determined using a time-frequency decomposition of the P300. Our preliminary results demonstrate a significant increase in P300 amplitude in the stimulation group which was accompanied by a decrease in omission errors pre-to-post tACS. However, studies including larger sample sizes are advised.

Indexed as

Event-Related Potentials, P300AdultAttention Deficit Disorder with HyperactivityBrainElectroencephalographyEvoked PotentialsFemaleHumansMalePilot ProjectsTranscranial Direct Current StimulationAttention deficit/hyperactivity disorderP300Transcranial alternating current stimulation

Identifiers

PMID31974733
PMCPMC7066286
OpenAlexW3001744042

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.