ArticlePlanta2020
Novel insights into expansion and functional diversification of MIR169 family in tomato.
Article in Planta, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 61 citations in OpenAlex.
- PagMIR166c targets PagECH2 to regulate cambial differentiation into secondary xylem, cell expansion, and lignin deposition via different auxin signaling pathways in poplar stems.The New phytologist · 2025Article
- Silencing of miR169a improves drought stress by enhancing vascular architecture, ROS scavenging, and photosynthesis ofFrontiers in plant science · 2025Article
- RNA Metabolism and the Role of Small RNAs in Regulating Multiple Aspects of RNA Metabolism.Non-coding RNA · 2024Review
- In silico analysis of L- and G-type lectin receptor kinases in tomato: evolution, diversity, and abiotic responses.BMC genomics · 2024Article
- Omics-Driven Strategies for Developing Saline-Smart Lentils: A Comprehensive Review.International journal of molecular sciences · 2024Review
- Genome-wide analysis of HD-Zip genes in Sophora alopecuroides and their role in salt stress response.The plant genome · 2024Article
- Review
- Identification of miRNAs Involved in Maize-Induced Systemic Resistance Primed byJournal of fungi (Basel, Switzerland) · 2023Article
- Coordinating Diverse Functions of miRNA and lncRNA in Fleshy Fruit.Plants (Basel, Switzerland) · 2023Review
- Tomato plant response to heat stress: a focus on candidate genes for yield-related traits.Frontiers in plant science · 2023Review
- Molecular Aspects of MicroRNAs and Phytohormonal Signaling in Response to Drought Stress: A Review.Current issues in molecular biology · 2022Review
- Identification of Known and NovelLife (Basel, Switzerland) · 2022Article
- An Integration of MicroRNA and Transcriptome Sequencing Analysis Reveal Regulatory Roles of miRNAs in Response to Chilling Stress in Wild Rice.Plants (Basel, Switzerland) · 2022Article
- Cultivar-biased regulation of HSFA7 and HSFB4a govern high-temperature tolerance in tomato.Planta · 2022Article
- miRNAs and lncRNAs in tomato: Roles in biotic and abiotic stress responses.Frontiers in plant science · 2022Review
- An Integrated Bioinformatics and Functional Approach for miRNA Validation.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Raising Climate-Resilient Crops: Journey From the Conventional Breeding to New Breeding Approaches.Current genomics · 2021Review
- MicroRNAs Involved in Regulatory Cytoplasmic Male Sterility by Analysis RNA-seq and Small RNA-seq in Soybean.Frontiers in genetics · 2021Article
- Identification and Functional Characterization of Plant MiRNA Under Salt Stress Shed Light on Salinity Resistance Improvement Through MiRNA Manipulation in Crops.Frontiers in plant science · 2021Review
- Aux/IAA14 Regulates microRNA-Mediated Cold Stress Response inInternational journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MAIN
conclusionExpansion of MIR169 members by duplication and new mature forms, acquisition of new promoters, differential precursor-miRNA processivity and engaging novel targets increase the functional diversification of MIR169 in tomato. MIR169 family is an evolutionarily conserved miRNA family in plants. A systematic in-depth analysis of MIR169 family in tomato is lacking. We report 18 miR169 precursors, annotating new loci for MIR169a, b and d, as well as 3 novel mature isoforms (MIR169f/g/h). The family has expanded by both tandem- and segmental-duplication events during evolution. A tandem-pair MIR169b/b-1 and MIR169b-2/h is polycistronic in nature coding for three MIR169b isoforms and a new variant miR169h, that is evidently absent in the wild relatives S. pennellii and S. pimpinellifolium. Seven novel miR169 targets including RNA-binding protein, protein-phosphatase, aminotransferase, chaperone, tetratricopeptide-repeat-protein, and transcription factors ARF-9B and SEPELLATA-3 were established by efficient target cleavage in the presence of specific precursors as well as increased target abundance upon miR169 chelation by short-tandem-target-mimic construct in transient assays. Comparative antagonistic expression profiles of MIR169:target pairs suggest MIR169 family as ubiquitous regulator of various abiotic stresses (heat, cold, dehydration and salt) and developmental pathways. This regulation is partly brought about by acquisition of new promoters as demonstrated by promoter MIR169:GUS reporter assays as well as differential processivity of different precursors and miRNA cleavage efficiencies. Thus, the current study augments the functional horizon of MIR169 family with applications for stress tolerance in crops.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.