Evidence map›Paper›PMID 31974507›Full record

ReviewNature reviews. Urology2020

Regenerative medicine and injection therapies in stress urinary incontinence.

Christopher J Hillary, Sabiniano Roman, Sheila MacNeil, Wilhelm K Aicher, Arnulf Stenzl, Christopher R Chapple

Erratum issuedAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Urology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Porcine-derived materials in urology Practical ethical guidance for caring for Muslim and Jewish patients.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2026
    Review
  6. Improved Sphincter Muscle Regeneration by Myoblasts fromMedical sciences (Basel, Switzerland) · 2026
    Article
  7. Article
  8. Observational
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  10. Article
  11. Article
  12. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Christopher J HillaryRoyal Hallamshire Hospital, Glossop Road, Sheffield, UK. chris.hillary@doctors.org.uk.
Sabiniano RomanDepartment of Materials Science and Engineering, Kroto Research Institute, University of Sheffield, Sheffield, UK.
Sheila MacNeilDepartment of Materials Science and Engineering, Kroto Research Institute, University of Sheffield, Sheffield, UK.
Wilhelm K AicherMembers of the Regenerative Sphincter Therapy (ReST) Consortium funded by the European Cooperation in Science and Technology (COST), Brussels, Belgium.
Arnulf StenzlMembers of the Regenerative Sphincter Therapy (ReST) Consortium funded by the European Cooperation in Science and Technology (COST), Brussels, Belgium.
Christopher R ChappleRoyal Hallamshire Hospital, Glossop Road, Sheffield, UK.
Royal Hallamshire Hospital · GBUniversity of Sheffield · GBSTZ eyetrial · DEUniversity of Tübingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stress urinary incontinence (SUI) is a common and bothersome condition. Anti-incontinence surgery has high cure rates, but concerns about mesh tapes have resulted in the resurgence of surgical procedures that involve increased abdominopelvic dissection and morbidity. Injection therapy with urethral bulking agents or stem cell formulations have been developed as minimally invasive alternatives. Many synthetic and biological bulking agents have been trialled, but several have been discontinued owing to safety concerns. The use of Macroplastique and Contigen has the largest evidence base, but, overall, success rates seem to be similar between the various agents and positive outcomes are poorly sustained for more than 6 months. Furthermore, subjective cure rates, although initially high, also deteriorate over time. The available data consistently demonstrate manifestly poorer outcomes for injection therapies than for surgery. Stem cell treatments are thought to functionally regenerate the urethral sphincter in patients with suspected intrinsic sphincter deficiency. Autologous adipose and muscle-derived stem cells seem to be the intuitive cell source, as they are comparatively abundant, can be harvested and cause minimal donor site morbidity. To date, only a few small clinical studies have been reported and most data are derived from animal models. The success rates of stem cell injection therapies seem to be comparable with those of bulking agents.

Indexed as

Biocompatible MaterialsHumansInjections, IntralesionalRegenerative MedicineStem Cell TransplantationUrethral DiseasesUrinary Incontinence, StressBiocompatible Materials

Identifiers

PMID31974507
OpenAlexW3001029683

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.