Evidence map›Paper›PMID 31974480›Full record

ArticleScientific reports2020

First in man study of [

Nicki J F Verweij, Maqsood Yaqub, Stefan T G Bruijnen, S Pieplenbosch, Marieke M Ter Wee, Gerrit Jansen, Qingshou Chen, Philip S Low, Albert D Windhorst, Adriaan A Lammertsma and 3 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 75 citations in OpenAlex.

  1. Review
  2. Tracking macrophages by direct and indirectEuropean journal of nuclear medicine and molecular imaging · 2026
    Article
  3. [ACS omega · 2026
    Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. SUVs Versus Dynamic Pharmacokinetic [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  12. Article
  13. Review
  14. Review
  15. Role of Total Body PET/CT in Inflammatory Disorders.Seminars in nuclear medicine · 2025
    Review
  16. Article
  17. Challenges in Pharmacokinetic Modelling of [Molecular imaging and biology · 2024
    Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Nicki J F VerweijAmsterdam Rheumatology and immunology Center (ARC), Amsterdam UMC| location VUmc, Amsterdam, the Netherlands.
Maqsood YaqubDepartment of Radiology & Nuclear Medicine, Amsterdam UMC| location VUmc, Amsterdam, The Netherlands.
Stefan T G BruijnenAmsterdam Rheumatology and immunology Center (ARC), Amsterdam UMC| location VUmc, Amsterdam, the Netherlands.
S PieplenboschDepartment of Radiology & Nuclear Medicine, Amsterdam UMC| location VUmc, Amsterdam, The Netherlands.
Marieke M Ter WeeAmsterdam Rheumatology and immunology Center (ARC), Amsterdam UMC| location VUmc, Amsterdam, the Netherlands.
Gerrit JansenAmsterdam Rheumatology and immunology Center (ARC), Amsterdam UMC| location VUmc, Amsterdam, the Netherlands.
Qingshou ChenDepartment of Chemistry and Institute for Drug Discovery, Purdue University, West Lafayette, IN, USA.
Philip S LowDepartment of Chemistry and Institute for Drug Discovery, Purdue University, West Lafayette, IN, USA.
Albert D WindhorstDepartment of Radiology & Nuclear Medicine, Amsterdam UMC| location VUmc, Amsterdam, The Netherlands.
Adriaan A LammertsmaDepartment of Radiology & Nuclear Medicine, Amsterdam UMC| location VUmc, Amsterdam, The Netherlands.
Otto S HoekstraDepartment of Radiology & Nuclear Medicine, Amsterdam UMC| location VUmc, Amsterdam, The Netherlands.
Alexandre E VoskuylAmsterdam Rheumatology and immunology Center (ARC), Amsterdam UMC| location VUmc, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0002-9699-1827
Conny J van der LakenAmsterdam Rheumatology and immunology Center (ARC), Amsterdam UMC| location VUmc, Amsterdam, the Netherlands. j.vanderlaken@amsterdamumc.nl.
Amsterdam University Medical Centers · NLPurdue University West Lafayette · USAmsterdam Neuroscience · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-invasive imaging of arthritis activity in rheumatoid arthritis (RA) patients using macrophage PET holds promise for early diagnosis and therapeutic response monitoring. Previously obtained results with macrophage tracer (R)-[

Indexed as

AgedArthritis, RheumatoidEarly DiagnosisFemaleFluorine RadioisotopesFolate Receptor 2Folic AcidHumansMacrophagesMaleMiddle AgedMolecular ImagingPolyethylene GlycolsPositron-Emission TomographySynovial MembraneFluorine RadioisotopesFolate Receptor 2Folic AcidFOLR2 protein, humanpoly(ethylene glycol)-folatePolyethylene Glycols

Identifiers

PMID31974480
PMCPMC6978456
OpenAlexW3002048103

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.