Evidence map›Paper›PMID 31974450›Full record

ArticleEuropean journal of clinical nutrition2020

Prenatal exposure to the Chinese famine and the risk of metabolic syndrome in adulthood across consecutive generations.

Shiwei Yan, Wanying Hou, Huanyu Wu, Wenbo Jiang, Yinling Li, Yuan Zhang, Hongyin Li, Sen Yang, Changhao Sun, Tianshu Han and 1 more

Abstract read
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Article in European journal of clinical nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Elevated risk of infectious diseases in adulthood after prenatal or early postnatal exposure to the Great Chinese Famine.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Shiwei YanDepartment of Nutrition and Food Hygiene, College of Public Health, Harbin Medical University, Harbin, 150081, Heilongjiang, PR China.
Wanying HouDepartment of Nutrition and Food Hygiene, College of Public Health, Harbin Medical University, Harbin, 150081, Heilongjiang, PR China.
Huanyu WuDepartment of Nutrition and Food Hygiene, College of Public Health, Harbin Medical University, Harbin, 150081, Heilongjiang, PR China.
Wenbo JiangDepartment of Nutrition and Food Hygiene, College of Public Health, Harbin Medical University, Harbin, 150081, Heilongjiang, PR China.
Yinling LiDepartment of Nutrition and Food Hygiene, College of Public Health, Harbin Medical University, Harbin, 150081, Heilongjiang, PR China.
Yuan ZhangDepartment of Nutrition and Food Hygiene, College of Public Health, Harbin Medical University, Harbin, 150081, Heilongjiang, PR China.
Hongyin LiDepartment of Nutrition and Food Hygiene, College of Public Health, Harbin Medical University, Harbin, 150081, Heilongjiang, PR China.
Sen YangDepartment of Nutrition and Food Hygiene, College of Public Health, Harbin Medical University, Harbin, 150081, Heilongjiang, PR China.
Changhao SunDepartment of Nutrition and Food Hygiene, College of Public Health, Harbin Medical University, Harbin, 150081, Heilongjiang, PR China. changhaosun2002@163.com.
Tianshu HanDepartment of Nutrition and Food Hygiene, College of Public Health, Harbin Medical University, Harbin, 150081, Heilongjiang, PR China. snowcalendar@126.com.
Ying LiDepartment of Nutrition and Food Hygiene, College of Public Health, Harbin Medical University, Harbin, 150081, Heilongjiang, PR China. liying_helen@163.com.

Funding

National Natural Science Foundation of China (National Science Foundation of China) 81803227
6 · The paper itself

Abstract

BACKGROUND/

objectivesThe purpose of our study was to explore the relation of prenatal exposure to the Chinese famine and the risk of metabolic syndrome in adulthood in consecutive generations. SUBJECTS/

methodsA total of 960 families, including 1920 parents (F1) who were born near the time of the Great Chinese famine and 1145 of their offspring (F2), were selected from the Suihua rural area. Parental participants were defined as nonexposed (born between 1 October 1956 and 30 September 1958 or between 1 October 1962 and 30 September 1964) and famine exposed (born between 1 October 1959 and 30 September 1961). In F2, participants were divided into having no parents exposed to famine, only a mother exposed to famine, only a father exposed to famine or both parents exposed to famine. Metabolic syndrome was defined by the International Diabetes Federation criteria.

resultsExposure to famine during gestation was associated with an increased risk of metabolic syndrome (odds ratio: 2.79, 95% confidence interval: 2.16, 3.60) in F1 adults. However, similar association was not observed (maternal: odds ratio: 1.33, 95% confidence interval: 0.69, 2.52; paternal: odds ratio: 1.67, 95% confidence interval: 0.87, 3.21; parental: odds ratio: 1.25, 95% confidence interval: 0.68, 2.31) in F2 adults.

conclusionsExposure to the Chinese famine during foetal life was associated with an increased risk of metabolic syndrome in F1 participants. In F2 adults, there might be an important relationship between exposure to famine and the risk of metabolic syndrome with increasing age.

Indexed as

Metabolic SyndromePrenatal Exposure Delayed EffectsStarvationAdultChinaFamineFemaleHumansPregnancyRisk Factors

Identifiers

PMID31974450

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