ArticleScientific reports2020
Mass spectrometry-based metabolomics approach in the isolation of bioactive natural products.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- The Computational Revolution in Natural Product Research: A Data-Driven Roadmap for Next-Generation Drug Development.Biology · 2026Review
- Antioxidant Activity, Phytochemical Characterization, and In Vitro Antitumor Effects of Foam-Mat Dried Mango (Mangifera indica L.) Pulp.Journal of food science · 2026Article
- Chemodiversity of Cyanobacteria from Brazil Investigated by Metabolomics and Bioassays.ACS omega · 2025Article
- Multi-omics approaches: transforming the landscape of natural product isolation.Functional & integrative genomics · 2025Review
- A comprehensive UHPLC-MS/MS and extraction method reveals flavonoid profile and concentration are diverse in spinach (Frontiers in plant science · 2025Article
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- An Integrated Strategy of UHPLC-ESI-MS/MS Combined with Bioactivity-Based Molecular Networking for Identification of Antitumoral Withanolides fromMolecules (Basel, Switzerland) · 2024Article
- A metabolomics perspective on clorobiocin biosynthesis: discovery of bromobiocin and novel derivatives through LC-MSMicrobiology spectrum · 2024Article
- Designing optimal experiments in metabolomics.Metabolomics : Official journal of the Metabolomic Society · 2024Review
- MultiplexMS: A Mass Spectrometry-Based Multiplexing Strategy for Ultra-High-Throughput Analysis of Complex Mixtures.Analytical chemistry · 2023Article
- MAW: the reproducible Metabolome Annotation Workflow for untargeted tandem mass spectrometry.Journal of cheminformatics · 2023Article
- Rosemary (Antioxidants (Basel, Switzerland) · 2023Article
- Metabolomic Strategies to Improve Chemical Information from OSMAC Studies of Endophytic Fungi.Metabolites · 2023Article
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- Hygrolansamycins A-D,Journal of microbiology and biotechnology · 2022Article
- High-Resolution Bioassay Profiling with Complemented Sensitivity and Resolution for Pancreatic Lipase Inhibitor Screening.Molecules (Basel, Switzerland) · 2022Article
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- Characterization of Constituents with Potential Anti-Inflammatory Activity in Chinese Lonicera Species by UHPLC-HRMS Based Metabolite Profiling.Metabolites · 2022Article
- Discovery of actinomycin L, a new member of the actinomycin family of antibiotics.Scientific reports · 2022Article
- Article
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Authors and funding
7 authors.
Funding
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Abstract
Metabolomics is a powerful tool in the analysis and identification of metabolites responsible for biological properties. Regarding natural product chemistry, it constitutes a potential strategy to streamline the classic and laborious process of isolating natural products, which often involves the re-isolation and identification of known compounds. In this contribution, we establish a mass spectrometry-based metabolomics strategy to discover compounds with larvicidal activity against Aedes aegypti. We analyse the Brazilian plant Annona crassiflora using different platforms to annotate the active compounds in different extracts/fractions of various plant parts. The MetaboAnalyst and GNPS platforms, which consider LC-MS and LC-MS/MS data, respectively, were chosen to identify compounds that differentiate active and inactive samples. Bio-guided isolation was subsequently performed to confirm compound activity. Results proved the capacity of metabolomics to predict metabolite differences between active and inactive samples using LC-MS and LC-MS/MS data. Moreover, we discuss the limitations, possibilities, and strategies to have a broad view of vast data.
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