Evidence map›Paper›PMID 31974304›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

GABA-mediated tonic inhibition differentially modulates gain in functional subtypes of cortical interneurons.

Alexander Bryson, Robert John Hatch, Bas-Jan Zandt, Christian Rossert, Samuel F Berkovic, Christopher A Reid, David B Grayden, Sean L Hill, Steven Petrou

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 54 citations in OpenAlex.

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  9. Identification and quantification of GABAIBRO neuroscience reports · 2025
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  20. A therapeutic small molecule enhances γ-oscillations and improves cognition/memory in Alzheimer's disease model mice.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Alexander BrysonIon Channels and Disease Group, The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC 3052, Australia; alexander.bryson@florey.edu.au steven.petrou@florey.edu.au.
Robert John HatchIon Channels and Disease Group, The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC 3052, Australia.
Bas-Jan ZandtBlue Brain Project, École Polytechnique Fédérale de Lausanne, 1202 Geneva, Switzerland.
Christian RossertBlue Brain Project, École Polytechnique Fédérale de Lausanne, 1202 Geneva, Switzerland.
Samuel F BerkovicEpilepsy Research Centre, Department of Medicine, University of Melbourne, Austin Health, Heidelberg, VIC 3084, Australia.ORCID 0000-0003-4580-841X
Christopher A ReidIon Channels and Disease Group, The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC 3052, Australia.
David B GraydenDepartment of Biomedical Engineering, University of Melbourne, Melbourne, VIC 3010, Australia.ORCID 0000-0002-5497-7234
Sean L HillBlue Brain Project, École Polytechnique Fédérale de Lausanne, 1202 Geneva, Switzerland.ORCID 0000-0001-8055-860X
Steven PetrouIon Channels and Disease Group, The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC 3052, Australia; alexander.bryson@florey.edu.au steven.petrou@florey.edu.au.
The University of Melbourne · AUÉcole Polytechnique Fédérale de Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The binding of GABA (γ-aminobutyric acid) to extrasynaptic GABA

Indexed as

Cerebral CortexInterneuronsAction PotentialsAnimalsgamma-Aminobutyric AcidKineticsMiceModels, NeurologicalNeural InhibitionPatch-Clamp Techniquesgamma-Aminobutyric AcidGABAinterneuron subtypesneuromodulationneuronal excitabilitytonic inhibition

Identifiers

PMID31974304
PMCPMC7022204
OpenAlexW3002870585

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.