ArticleJournal of the American Society of Nephrology : JASN2020
Kidney Structural Features from Living Donors Predict Graft Failure in the Recipient.
Article in Journal of the American Society of Nephrology : JASN, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- Artificial Intelligence in Kidney Transplant Pathology: Current Evidence, Limitations, and Relevance to the Banff Framework.Kidney international reports · 2026Review
- Superior transplant recipient outcome prediction and pathology assessment using rapid deep learning applied to procurement kidney biopsies.Scientific reports · 2025Article
- Longitudinal multi-b-value diffusion-weighted imaging in renal transplant recipients: diagnostic efficacy and prognostic value for allograft dysfunction.Quantitative imaging in medicine and surgery · 2025Article
- Chronic Changes on Kidney Histology by a Multiclass Artificial Intelligence Model.Kidney international reports · 2025Article
- Fewer medullary pyramids in the living kidney donor are associated with graft failure in the recipient.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025Article
- Evaluation of early donor renal function recovery after living-donor nephrectomy as a predictor of allograft failure after kidney transplantation: a longitudinal cohort and machine learning study.EClinicalMedicine · 2025Article
- The impact of living donor hypertension on later function of kidney graft in kidney transplantation.Frontiers in medicine · 2025Article
- Adaptive Glomerular Hypertrophy in Kidney Transplants Associated With Focal Segmental Glomerulosclerosis: Report of Three Cases.Case reports in nephrology · 2025Article
- Heterogeneous afferent arteriolopathy: a key concept for understanding blood pressure-dependent renal damage.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Review
- Clinical and histopathological characteristics of acute kidney injury in a cohort of brain death donors with procurement biopsies.Journal of nephrology · 2024Article
- Association of Implantation Biopsy Findings in Living Donor Kidneys With Donor and Recipient Outcomes.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2024Article
- Morphometric analysis of chronicity on kidney biopsy: a useful prognostic exercise.Clinical kidney journal · 2024Review
- Recognition of intraglomerular histological features with deep learning in protocol transplant biopsies and their association with kidney function and prognosis.Clinical kidney journal · 2024Article
- Presumed Monozygotic Twin Kidney Transplantation with a Thin Basement Membrane Nephropathy Donor: A Case Report.Acta medica Philippina · 2024Article
- Changes in Glomerular Volume, Sclerosis, and Ischemia at 5 Years after Kidney Transplantation: Incidence and Correlation with Late Graft Failure.Journal of the American Society of Nephrology : JASN · 2023Article
- Long-term Medical Outcomes of Living Kidney Donors.Mayo Clinic proceedings · 2022Review
- Kidney glomerular filtration rate plasticity after transplantation.Clinical kidney journal · 2022Article
- Basic principles and new advances in kidney imaging.Kidney international · 2021Review
- Human kidney graft survival correlates with structural parameters in baseline biopsies: a quantitative observational cohort study with more than 14 years' follow-up.Virchows Archiv : an international journal of pathology · 2021Observational
- Aorto-Iliac Artery Calcification and Graft Outcomes in Kidney Transplant Recipients.Journal of clinical medicine · 2021Article
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundNephrosclerosis, nephron size, and nephron number vary among kidneys transplanted from living donors. However, whether these structural features predict kidney transplant recipient outcomes is unclear.
methodsOur study used computed tomography (CT) and implantation biopsy to investigate donated kidney features as predictors of death-censored graft failure at three transplant centers participating in the Aging Kidney Anatomy study. We used global glomerulosclerosis, interstitial fibrosis/tubular atrophy, artery luminal stenosis, and arteriolar hyalinosis to measure nephrosclerosis; mean glomerular volume, cortex volume per glomerulus, and mean cross-sectional tubular area to measure nephron size; and calculations from CT cortical volume and glomerular density on biopsy to assess nephron number. We also determined the death-censored risk of graft failure with each structural feature after adjusting for the predictive clinical characteristics of donor and recipient.
resultsThe analysis involved 2293 donor-recipient pairs. Mean recipient follow-up was 6.3 years, during which 287 death-censored graft failures and 424 deaths occurred. Factors that predicted death-censored graft failure independent of both donor and recipient clinical characteristics included interstitial fibrosis/tubular atrophy, larger cortical nephron size (but not nephron number), and smaller medullary volume. In a subset with 12 biopsy section slides, arteriolar hyalinosis also predicted death-censored graft failure.
conclusionsSubclinical nephrosclerosis, larger cortical nephron size, and smaller medullary volume in healthy donors modestly predict death-censored graft failure in the recipient, independent of donor or recipient clinical characteristics. These findings provide insights into a graft's "intrinsic quality" at the time of donation, and further support the use of intraoperative biopsies to identify kidney grafts that are at higher risk for failure.
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