Evidence map›Paper›PMID 31974114›Full record

ArticleJournal of cell science2020

Vav2 lacks Ca

Michael A Fray, John C Charpentier, Nicholas R Sylvain, Maria-Cristina Seminario, Stephen C Bunnell

Open access · greenAbstract read
In one paragraph

Article in Journal of cell science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Michael A FrayProgram in Immunology, Department of Immunology, Tufts University School of Medicine, Boston, MA 02111, USA.ORCID 0000-0001-8388-1875
John C CharpentierDepartment of Biology, University of Massachusetts Boston, Boston, MA 02125, USA.ORCID 0000-0001-9488-8239
Nicholas R SylvainProgram in Immunology, Department of Immunology, Tufts University School of Medicine, Boston, MA 02111, USA.
Maria-Cristina SeminarioProgram in Immunology, Department of Immunology, Tufts University School of Medicine, Boston, MA 02111, USA.ORCID 0000-0003-0762-8661
Stephen C BunnellProgram in Immunology, Department of Immunology, Tufts University School of Medicine, Boston, MA 02111, USA stephen.bunnell@tufts.edu.ORCID 0000-0001-6887-0828
Tufts University · USUniversity of Massachusetts Boston · US

Funding

Initiative for Maximizing Student Diversity at UMass BostonR25GM076321 · NIGMS · UNIVERSITY OF MASSACHUSETTS BOSTON · PI COLON-CARMONA, ADAN, SKVIRSKY, RACHEL · 2008 to 2022
$4.5M
IMMUNOLOGIC ASPECTS OF DISEASET32AI007077 · NIAID · TUFTS UNIVERSITY BOSTON · PI WORTIS, HENRY H. · 1985 to 2017
$3.5M
Mechanisms of Integrin-Mediated Costimulation in T CellsR01AI076575 · NIAID · TUFTS UNIVERSITY BOSTON · PI BUNNELL, STEPHEN C · 2009 to 2013
$1.9M
NIAID NIH HHS R01 AI076575NIAID NIH HHS T32 AI007077NIGMS NIH HHS R25 GM076321
6 · The paper itself

Abstract

Vav family guanine nucleotide exchange factors (GEFs) are essential regulators of immune function. Despite their structural similarity, Vav1 promotes and Vav2 opposes T cell receptor (TCR)-induced Ca

Indexed as

Lymphocyte ActivationProto-Oncogene Proteins c-vavProtein IsoformsReceptors, Antigen, T-CellT-LymphocytesProtein IsoformsProto-Oncogene Proteins c-vavReceptors, Antigen, T-CellCa2+CalciumCdc42Rac1T cellVav1Vav2

Identifiers

PMID31974114
PMCPMC7075049
OpenAlexW3002015418

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.