Evidence map›Paper›PMID 31974100›Full record

ArticleDiabetes care2020

Diabetic Neuropathy Is a Substantial Burden in People With Type 1 Diabetes and Is Strongly Associated With Socioeconomic Disadvantage: A Population-Representative Study From Scotland.

Anita Jeyam, Stuart J McGurnaghan, Luke A K Blackbourn, John M McKnight, Fiona Green, Andrew Collier, Paul M McKeigue, Helen M Colhoun, SDRNT1BIO Investigators

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Diabetes care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 3 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 56 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2022
    Guideline
  4. Review
  5. Article
  6. Article
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  8. Article
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  10. Article
  11. Review
  12. Diabetic neuropathy: cutting-edge research and future directions.Signal transduction and targeted therapy · 2025
    Review
  13. Article
  14. Review
  15. Article
  16. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Anita JeyamMRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, U.K. anita.jeyam@igmm.ed.ac.uk.ORCID 0000-0001-8701-0233
Stuart J McGurnaghanMRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, U.K.
Luke A K BlackbournMRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, U.K.
John M McKnightWestern General Hospital, NHS Lothian, Edinburgh, U.K.
Fiona GreenResearch and Development Support Unit, Dumfries and Galloway Royal Infirmary, Dumfries, U.K.
Andrew CollierDiabetic Day Centre, University Hospital Ayr, Ayr, U.K.ORCID 0000-0001-5220-6244
Paul M McKeigueCentre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, Edinburgh Medical School: Molecular, Genetic and Population Health Sciences, University of Edinburgh, Edinburgh, U.K.
SDRNT1BIO Investigators
Institute of Genetics and Cancer · GBDumfries and Galloway Royal Infirmary · GBGlasgow Centre for Population Health · GBNHS Fife · GBNHS Lothian · GBUniversity Hospital Ayr · GB

Funding

Chief Scientist Office ETM/47Diabetes UK 10/0004010
6 · The paper itself

Abstract

objectiveTo assess the contemporaneous prevalence of diabetic peripheral neuropathy (DPN) in people with type 1 diabetes (T1D) in Scotland and study its cross-sectional association with risk factors and other diabetic complications. RESEARCH DESIGN AND

methodsWe analyzed data from a large representative sample of adults with T1D (

resultsThe burden of DPN is substantial with 13% prevalence overall. Adjusting for attained age, diabetes duration, and sex, the odds of DPN increased mainly with waist-to-hip ratio, lipids, poor glycemic control (odds ratio 1.51 [95% CI 1.21-1.89] for levels of 75 vs. 53 mmol/mol), ever versus never smoking (1.67 [1.37-2.03]), and worse renal function (1.96 [1.03-3.74] for estimated glomerular filtration rate levels <30 vs. ≥90 mL/min/1.73 m

conclusionsDiabetic neuropathy remains substantial, particularly affecting those in the most socioeconomically deprived groups. Those with clinically manifest neuropathy also have a higher burden of other complications and elevated levels of modifiable risk factors. These data suggest that there is considerable scope to reduce neuropathy rates and narrow the socioeconomic differential by better risk factor control.

Indexed as

AdolescentAdultCross-Sectional StudiesDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2Diabetic NeuropathiesFemaleHumansMaleMiddle AgedPrevalenceRisk FactorsScotlandSocioeconomic FactorsVulnerable PopulationsYoung Adult

Identifiers

PMID31974100
OpenAlexW3002419256

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.