ArticleNeuron2020
LRRTM4: A Novel Regulator of Presynaptic Inhibition and Ribbon Synapse Arrangements of Retinal Bipolar Cells.
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Article in Neuron, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
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29 citing papers in PubMed, 42 citations in OpenAlex.
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- Single-nucleus transcriptomics identifies cell cycle and synaptic pathway dysregulation during OPC-to-glioma progression.Frontiers in cellular neuroscience · 2026Article
- Afferent input differentially regulates establishment and maintenance of synapses in the mammalian retina.Scientific reports · 2025Article
- Cross-species mapping of psychedelic gene expression reveals links to the 5HT2A receptor, cortical layers, and human accelerated regions.Research square · 2025Article
- Divergent mechanisms of neural adaptation and instability in the mammalian retina.Current biology : CB · 2025Article
- Deficiency of the Synaptic Adhesion Protein Leucine-Rich Repeat Transmembrane Protein 4 Like 1 Affects Anxiety and Aggression in Zebrafish.Acta physiologica (Oxford, England) · 2025Article
- Molecular mechanism establishing the OFF pathway in vision.Nature communications · 2025Article
- Insights into the Pathobiology of GM1 Gangliosidosis from Single-Nucleus Transcriptomic Analysis of CNS Cells in a Mouse Model.International journal of molecular sciences · 2024Article
- Cellular and Molecular Mechanisms Regulating Retinal Synapse Development.Annual review of vision science · 2024Review
- Synaptic promiscuity in brain development.Current biology : CB · 2024Review
- Article
- Adjuvant crizotinib treatment selected by patient-derived organoids in a patient with stage IIIA adenocarcinoma with novelTranslational lung cancer research · 2023Article
- Sensory deprivation arrests cellular and synaptic development of the night-vision circuitry in the retina.Current biology : CB · 2023Article
- Lnc-LRRTM4 promotes proliferation, metastasis and EMT of colorectal cancer through activating LRRTM4 transcription.Cancer cell international · 2023Article
- LRIT3 expression in cone photoreceptors restores post-synaptic bipolar cell signalplex assembly and partial function iniScience · 2023Article
- Distinctive synaptic structural motifs link excitatory retinal interneurons to diverse postsynaptic partner types.Cell reports · 2023Article
- Sex differences in the genetics of sarcoidosis across European and African ancestry populations.Frontiers in medicine · 2023Article
- Trophoblast glycoprotein is required for efficient synaptic vesicle exocytosis from retinal rod bipolar cells.Frontiers in cellular neuroscience · 2023Article
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Authors and funding
10 authors at 5 institutions in 2 countries.
Raunak SinhaDepartment of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, USA; McPherson Eye Research Institute, University of Wisconsin, Madison, WI, USA; Department of Physiology and Biophysics, University of Washington, Seattle, WA, USA.
Tabrez J SiddiquiDepartment of Physiology and Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0J9, Canada; Neuroscience Research Program, Kleysen Institute for Advanced Medicine, Health Sciences Center, Winnipeg, MB R3E 0Z3, Canada; The Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada.
Nirmala PadmanabhanDepartment of Physiology and Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0J9, Canada; Neuroscience Research Program, Kleysen Institute for Advanced Medicine, Health Sciences Center, Winnipeg, MB R3E 0Z3, Canada; The Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada.
Julie WallinDepartment of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, USA.
Chi ZhangDepartment of Biological Structure, University of Washington, Seattle, WA, USA.
Benyamin KarimiDepartment of Physiology and Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0J9, Canada; Neuroscience Research Program, Kleysen Institute for Advanced Medicine, Health Sciences Center, Winnipeg, MB R3E 0Z3, Canada; The Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada.
Fred RiekeDepartment of Physiology and Biophysics, University of Washington, Seattle, WA, USA.
Ann Marie CraigDjavad Mowafaghian Centre for Brain Health and Department of Psychiatry, University of British Columbia, Vancouver, BC V6T 2B5, Canada.
Rachel O WongDepartment of Biological Structure, University of Washington, Seattle, WA, USA.
Mrinalini HoonMcPherson Eye Research Institute, University of Wisconsin, Madison, WI, USA; Department of Biological Structure, University of Washington, Seattle, WA, USA. Electronic address: mhoon@wisc.edu.
University of Washington · USChildren's Hospital Research Institute of Manitoba · CAUniversity of Wisconsin–Madison · USUniversity of British Columbia · CAUniversity of Manitoba · CA
Funding
Vision Research CoreP30EY001730 · NEI · UNIVERSITY OF WASHINGTON · PI JAMES Bryant HURLEY · 1985 to 2026
$23.5MINTERCELLULAR COMMUNICATION IN RETINAL DEVELOPMENTR01EY010699 · NEI · WASHINGTON UNIVERSITY · PI WONG, RACHEL O · 1994 to 2024
$8.6MBIOPHYSICAL MECHANISMS OF SINGLE PHOTON DETECTIONR01EY011850 · NEI · UNIVERSITY OF WASHINGTON · PI RIEKE, FREDERICK M · 1997 to 2015
$3.5MRetinal interactions between rod and cone signalsR01EY028111 · NEI · UNIVERSITY OF WASHINGTON · PI RIEKE, FREDERICK M · 2017 to 2021
$1.9MRole of synaptic integration in early visual processingR00EY026070 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI SINHA, RAUNAK · 2018 to 2020
$747kRole of synaptic integration in early visual processingK99EY026070 · NEI · UNIVERSITY OF WASHINGTON · PI SINHA, RAUNAK · 2016 to 2017
$180kCIHR FDN-143206NEI NIH HHS K99 EY026070NEI NIH HHS P30 EY001730NEI NIH HHS R00 EY026070NEI NIH HHS R01 EY010699NEI NIH HHS R01 EY011850NEI NIH HHS R01 EY028111
Abstract
LRRTM4 is a transsynaptic adhesion protein regulating glutamatergic synapse assembly on dendrites of central neurons. In the mouse retina, we find that LRRTM4 is enriched at GABAergic synapses on axon terminals of rod bipolar cells (RBCs). Knockout of LRRTM4 reduces RBC axonal GABA
Indexed as
AnimalsFemalegamma-Aminobutyric AcidMaleMembrane ProteinsMiceMice, KnockoutMice, TransgenicNerve Tissue ProteinsNeural InhibitionPresynaptic TerminalsReceptors, GABARetinaRetinal Bipolar CellsVesicular Inhibitory Amino Acid Transport ProteinsGABA-C receptorgamma-Aminobutyric AcidLRRTM4 protein, mouseMembrane ProteinsNerve Tissue ProteinsReceptors, GABAVesicular Inhibitory Amino Acid Transport ProteinsViaat protein, mousebipolar cellGABA receptorLRRTMpresynaptic inhibitionretinaribbon synapsesynaptic adhesion protein
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.