Evidence map›Paper›PMID 31973992›Full record

ReviewCytokine & growth factor reviews2020

Human Papillomavirus and carcinogenesis: Novel mechanisms of cell communication involving extracellular vesicles.

Maria Vincenza Chiantore, Giorgio Mangino, Marco Iuliano, Lorena Capriotti, Paola Di Bonito, Gianna Fiorucci, Giovanna Romeo

Open access · greenAbstract readReview
In one paragraph

Review in Cytokine & growth factor reviews, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
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  10. Review
  11. Extracellular Vesicles in Viral Infections: Two Sides of the Same Coin?Frontiers in cellular and infection microbiology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Maria Vincenza ChiantoreDepartment of Infectious Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.
Giorgio ManginoDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, C.so della Repubblica 79, 04100, Latina, Italy.
Marco IulianoDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, C.so della Repubblica 79, 04100, Latina, Italy.
Lorena CapriottiDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, C.so della Repubblica 79, 04100, Latina, Italy.
Paola Di BonitoDepartment of Infectious Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.
Gianna FiorucciDepartment of Infectious Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy; Institute of Molecular Biology and Pathology, Consiglio Nazionale delle Ricerche, Piazzale Aldo Moro 5, 00161, Rome, Italy.
Giovanna RomeoDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, C.so della Repubblica 79, 04100, Latina, Italy; Institute of Molecular Biology and Pathology, Consiglio Nazionale delle Ricerche, Piazzale Aldo Moro 5, 00161, Rome, Italy. Electronic address: giovanna.romeo@uniroma1.it.
Sapienza University of Rome · ITIstituto Superiore di Sanità · ITInstitute of Molecular Biology and Pathology · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A small group of mucosal Human Papillomaviruses are the causative agents of cervical cancer and are also associated with other types of cancers. Certain cutaneous Human Papillomaviruses seem to have a role as co-factors in the UV-induced carcinogenesis of the skin. The main mechanism of the tumorigenesis induced by Human Papillomaviruses is linked to the transforming activity of the viral E6 and E7 oncoproteins. However, other mechanisms, such as the gene expression control by specific microRNAs expression and deregulation of immune inflammatory mediators, may be important in the process of transformation. In this context, the release of Extracellular Vesicles with a specific cargo (microRNAs involved in tumorigenesis, mRNAs of viral oncoproteins, cytokines, chemokines) appears to play a key role.

Indexed as

Cell CommunicationAlphapapillomavirusCarcinogenesisCarcinoma, Squamous CellExtracellular VesiclesFemaleHumansMicroRNAsPapillomavirus InfectionsRNA, MessengerSkinUterine Cervical NeoplasmsMicroRNAsRNA, MessengerExtracellular vesiclesInflammatory cytokines and chemokinesMicroRNAsMucosal and cutaneous HPVsα-and β-HPVs

Identifiers

PMID31973992
PMCPMC7108386
OpenAlexW2999939839

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.