Evidence map›Paper›PMID 31973952›Full record

ReviewUltrasound in medicine & biology2020

Super-resolution Ultrasound Imaging.

Kirsten Christensen-Jeffries, Olivier Couture, Paul A Dayton, Yonina C Eldar, Kullervo Hynynen, Fabian Kiessling, Meaghan O'Reilly, Gianmarco F Pinton, Georg Schmitz, Meng-Xing Tang and 2 more

2 registry-linked trialsOpen access · greenAbstract readReview
In one paragraph

Review in Ultrasound in medicine & biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 168 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
168citing papers in PubMed, 1 pooled it
23.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05754814 completednot on this mapstarted 2022, after this paper: background citation

SUper-Resolution Ultrasound Imaging of Erythrocytes (SURE) in Normal and Malignant Lymph Nodes

TypeobservationalSponsorRigshospitalet, DenmarkRan2022 to 2026Enrolled20ConditionsHead and Neck Cancer, Lymphoma, Lymph Node MetastasisArmsMalignant lymph nodes
NCT06793839 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Pilot Study : Characterization of Early Brain Injury and Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage by Ultrasound Localization Microscopy (ULM) 3D with an Experimental Medical Device (ESRIR)

TypeinterventionalSponsorUniversity Hospital, CaenRan2024 to 2025Enrolled15ConditionsSubarachnoid HemorrhageArmsTranscranial Enhanced Ultrasonography localizing microscopy
3 · Its place in the literature

Who cites it

168 citing papers in PubMed, 1 synthesis or guideline pooled it, 525 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Endothelial Continuum and Capillary Specialization in Pulmonary Vascular Development.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
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108 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 10 institutions in 6 countries.

Kirsten Christensen-JeffriesDepartment of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, London, United Kingdom.
Olivier CoutureInstitute of Physics for Medicine Paris, Inserm U1273, ESPCI Paris, CNRS FRE 2031, PSL University, Paris, France. Electronic address: olivier.couture@sorbonne-universite.fr.
Paul A DaytonJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, North Carolina, USA.
Yonina C EldarDepartment of Mathematics and Computer Science, Weizmann Institute of Science, Rehovot, Israel.
Kullervo HynynenPhysical Sciences Platform, Sunnybrook Research Institute, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Canada; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.
Fabian KiesslingInstitute for Experimental Molecular Imaging, RWTH Aachen University, Aachen, Germany.
Meaghan O'ReillyPhysical Sciences Platform, Sunnybrook Research Institute, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Canada.
Gianmarco F PintonJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, North Carolina, USA.
Georg SchmitzChair for Medical Engineering, Faculty for Electrical Engineering and Information Technology, Ruhr University Bochum, Bochum, Germany.
Meng-Xing TangDepartment of Bioengineering, Imperial College London, London, United Kingdom.
Mickael TanterInstitute of Physics for Medicine Paris, Inserm U1273, ESPCI Paris, CNRS FRE 2031, PSL University, Paris, France.
Ruud J G van SlounDepartment of Electrical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
Canada Research Chairs · CAPhysique pour la médecine ParisEindhoven University of Technology · NLImperial College London · GBKing's College London · GBNorth Carolina State University · USRuhr University Bochum · DEUniversitätsklinikum Aachen · DEUniversity of North Carolina at Chapel Hill · USWeizmann Institute of Science · IL

Funding

High Frame Rate 3-D Super Resolution Ultrasound Microvascular ImagingR01CA220681 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAYTON, PAUL A, PINTON, GIANMARCO · 2017 to 2022
$3.0M
An academic industrial partnership for the development of high frame-rate transcranial super resolution ultrasound imagingR01EB025149 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAYTON, PAUL A, PINTON, GIANMARCO · 2017 to 2018
$935k
Medical Research Council MR/S023542/1NCI NIH HHS R01 CA220681NIBIB NIH HHS R01 EB025149
6 · The paper itself

Abstract

The majority of exchanges of oxygen and nutrients are performed around vessels smaller than 100 μm, allowing cells to thrive everywhere in the body. Pathologies such as cancer, diabetes and arteriosclerosis can profoundly alter the microvasculature. Unfortunately, medical imaging modalities only provide indirect observation at this scale. Inspired by optical microscopy, ultrasound localization microscopy has bypassed the classic compromise between penetration and resolution in ultrasonic imaging. By localization of individual injected microbubbles and tracking of their displacement with a subwavelength resolution, vascular and velocity maps can be produced at the scale of the micrometer. Super-resolution ultrasound has also been performed through signal fluctuations with the same type of contrast agents, or through switching on and off nano-sized phase-change contrast agents. These techniques are now being applied pre-clinically and clinically for imaging of the microvasculature of the brain, kidney, skin, tumors and lymph nodes.

Indexed as

AnimalsBlood VesselsHumansMicrobubblesNeoplasmsUltrasonographyBrainContrast agentsLocalizationMicrobubblesMicroscopyMicrovesselsSuper-resolutionTumorUltrasound

Identifiers

PMID31973952
PMCPMC8388823
OpenAlexW3000957625

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.