Evidence map›Paper›PMID 31973719›Full record

ArticleJournal of translational medicine2020

Role of IL-24 in the mucosal remodeling of children with coeliac disease.

Réka Rokonay, Apor Veres-Székely, Beáta Szebeni, Domonkos Pap, Rita Lippai, Nóra J Béres, Gábor Veres, Attila J Szabó, Ádám Vannay

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Interleukin-24 in type 2 immune diseases.Frontiers in immunology · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Screening inflammatory protein biomarkers on premature infants with necrotizing enterocolitis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023
    Article
  7. Article
  8. Interleukin-24 Immunobiology and Its Roles in Inflammatory Diseases.International journal of molecular sciences · 2022
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Réka Rokonay1st Department of Paediatrics, Semmelweis University, 54 Bókay Street, Budapest, 1083, Hungary.
Apor Veres-Székely1st Department of Paediatrics, Semmelweis University, 54 Bókay Street, Budapest, 1083, Hungary.
Beáta SzebeniMTA-SE Paediatrics and Nephrology Research Group, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary.
Domonkos PapMTA-SE Paediatrics and Nephrology Research Group, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary.
Rita Lippai1st Department of Paediatrics, Semmelweis University, 54 Bókay Street, Budapest, 1083, Hungary.
Nóra J Béres1st Department of Paediatrics, Semmelweis University, 54 Bókay Street, Budapest, 1083, Hungary.
Gábor VeresPediatric Institute-Clinic, University of Debrecen, Debrecen, Hungary.
Attila J Szabó1st Department of Paediatrics, Semmelweis University, 54 Bókay Street, Budapest, 1083, Hungary.
Ádám Vannay1st Department of Paediatrics, Semmelweis University, 54 Bókay Street, Budapest, 1083, Hungary. vannay.adam@med.semmelweis-univ.hu.
Semmelweis University · HUHungarian Academy of Sciences · HUUniversity of Debrecen · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecently, involvement of IL-19, IL-20 and IL-24 has been reported in inflammatory diseases associated with tissue remodeling. However, their impact on the pathomechanism of coeliac disease (CD) is still completely unknown.

methodsExpression of IL19, IL20 and IL24 was measured by real-time RT-PCR, protein amount of IL-24, α smooth muscle actin (α-SMA) and fibronectin (FN) was determined by Western-blot analysis in the duodenal biopsies of therapy naive children with CD and controls. Localization of IL-24 and IL-20RB was investigated by immunofluorescent staining in the duodenal mucosa. Effect of recombinant IL-1β, TNF-α, TGF-β and IL-17 treatment on the expression of IL19, IL20, IL24 and their receptors was investigated by real-time RT-PCR in small intestinal epithelial cells (FHs74Int), in primary duodenal myofibroblasts (pdMFs) and in peripheral blood mononuclear cells (PBMCs). Effect of IL-24 on H

resultsWe found increased level of IL-24 (3.3×, p < 0.05), α-SMA (2.4×, p < 0.05) and FN (2.3×, p < 0.05) in the duodenal mucosa and increased expression of IL19 (3.6×, p < 0.05) and IL24 (5.2×, p < 0.05) in the PBMCs of children with CD compared to that of controls. IL-1β was a strong inducer of IL24 expression of FHs74Int cells (9.9×, p < 0.05), pdMFs (552.9×, p < 0.05) or PBMCs (17.2×, p < 0.05), as well. IL-24 treatment reduced the number of apoptotic cells (0.5×, p < 0.05) and decreased the expression of inflammatory factors, including IL1A, IL6 and TNF of H

conclusionOur results suggest that IL-24 plays a significant role in the maintenance of duodenal mucosal integrity in CD.

Indexed as

Celiac DiseaseAdolescentChildChild, PreschoolHumansHydrogen PeroxideInterleukin-24InterleukinsIntestinal MucosaLeukocytes, MononuclearMyofibroblastsHydrogen PeroxideInterleukin-24InterleukinsCoeliac diseaseEpithelial cellInterleukin 20 subfamilyInterleukin 24MyofibroblastPeripheral blood mononuclear cells (PBMC)Tissue remodeling

Identifiers

PMID31973719
PMCPMC6977354
OpenAlexW3010443948

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.