ArticleJournal of neurotrauma2020
Acute Cardiovascular Responses to Vagus Nerve Stimulation after Experimental Spinal Cord Injury.
Article in Journal of neurotrauma, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 17 citations in OpenAlex.
- Safety and feasibility of paired vagus nerve stimulation with rehabilitation for improving upper extremity function in people with cervical spinal cord injury: a pilot randomized controlled trial.Frontiers in rehabilitation sciences · 2026Trial
- Trial
- Targeting the gut microbiota to promote motor rehabilitation after spinal cord injury: mechanisms, evidence, and translational challenges.Frontiers in neurology · 2026Review
- "Chronic Cervical Midline Contusion in Rats Disrupts Aerobic, Muscular, and Cardiovascular Function".bioRxiv : the preprint server for biology · 2025Article
- Enhancing Neuroplasticity via vagus nerve stimulation to improve urinary dysfunction after spinal cord injury: a perspective.Bioelectronic medicine · 2025Review
- Advice for translational neuroscience: move deliberately and build things.Bioelectronic medicine · 2025Article
- Recent Trends in Physical Therapy Interventions and Neuromodulation Techniques to Improve Neurorehabilitation.CNS & neurological disorders drug targets · 2025Review
- Safety and feasibility of paired vagus nerve stimulation with rehabilitation for improving upper extremity function in people with cervical spinal cord injury: study protocol for a pilot randomized controlled trial.Frontiers in neurology · 2024Article
- Narrative review of current neuromodulation modalities for spinal cord injury.Frontiers in pain research (Lausanne, Switzerland) · 2023Review
- Consequences of spinal cord injury on the sympathetic nervous system.Frontiers in cellular neuroscience · 2023Review
- Exploring the vagus nerve and the inflammatory reflex for therapeutic benefit in chronic spinal cord injury.Current opinion in neurology · 2022Review
- Dynamic detection and reversal of myocardial ischemia using an artificially intelligent bioelectronic medicine.Science advances · 2022Article
- The role of electrical stimulation for rehabilitation and regeneration after spinal cord injury.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2022Review
- Rebuilding Body-Brain Interaction from the Vagal Network in Spinal Cord Injuries.Brain sciences · 2021Article
- Autonomic modulation of neuroplasticity in spinal cord injury rehabilitation: insights from a narrative review.Frontiers in neurologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Pairing vagus nerve stimulation (VNS) with rehabilitation has emerged as a potential strategy to enhance plasticity and improve recovery in a range of neurological disorders. A recent study highlights the therapeutic promise of VNS in promoting motor recovery after spinal cord injury (SCI). We investigated the safety of acute VNS in a rat model of chronic SCI. We measured the cardiovascular response to various VNS paradigms following chronic high-thoracic SCI that is known to deleteriously impact cardiovascular control. Dose-response experiments with continuous VNS revealed an SCI-dependent increase in sensitivity for heart rate (HR) and blood pressure (BP) compared with controls. A clinically relevant intermittent VNS resulted in transient reduction in HR in rats with SCI; however, BP remained unaltered. In all experiments, the effect lasted only while the VNS stimulus train was present, as HR and BP restored to baseline values as soon as VNS ended. No prolonged episodes of persisting hypotension were seen in either group. Further, VNS did not trigger autonomic dysreflexia or exacerbate the severity of autonomic dysreflexia when induced during or after stimulation sessions. Overall, these findings provide initial evidence that intermittent VNS at parameters used for targeted plasticity therapy (30 Hz, 0.8 mA) appears safe and supports further investigation of this potential therapy for use following SCI.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.