Evidence map›Paper›PMID 31973605›Full record

ArticleJournal of the American Heart Association2020

Inhibition of SREBP Improves Cardiac Lipidopathy, Improves Endoplasmic Reticulum Stress, and Modulates Chronic Chagas Cardiomyopathy.

Janeesh Plakkal Ayyappan, Kezia Lizardo, Sean Wang, Edward Yurkow, Jyothi F Nagajyothi

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

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  13. Sex Differences in Cardiac Pathology of SARS-CoV2 Infected andFrontiers in cardiovascular medicine · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Janeesh Plakkal AyyappanDepartment of Microbiology, Biochemistry and Molecular Genetics Public Health Research Institute New Jersey Medical School Newark NY.
Kezia LizardoDepartment of Microbiology, Biochemistry and Molecular Genetics Public Health Research Institute New Jersey Medical School Newark NY.
Sean WangRutgers Molecular Imaging Center Piscataway NJ.
Edward YurkowRutgers Molecular Imaging Center Piscataway NJ.
Jyothi F NagajyothiDepartment of Microbiology, Biochemistry and Molecular Genetics Public Health Research Institute New Jersey Medical School Newark NY.
Rutgers New Jersey Medical SchoolImaging Center · USRutgers, The State University of New Jersey · US

Funding

Pathogenic contribution of lipid homeostasis to chagasic CardiomyopathyR01HL122866 · NHLBI · RBHS-NEW JERSEY MEDICAL SCHOOL · PI NAGAJYOTHI, JYOTHI FALGUNI · 2015 to 2018
$1.6M
NHLBI NIH HHS R01 HL122866
6 · The paper itself

Abstract

Background

Indexed as

AnimalsBetulinic AcidCell LineChagas CardiomyopathyChronic DiseaseDisease Models, AnimalEndoplasmic Reticulum StressHost-Parasite InteractionsLipid MetabolismMaleMice, Inbred C3HMyocytes, CardiacRatsSterol Regulatory Element Binding ProteinsTriterpenesTrypanosoma cruzibetulinBetulinic AcidSterol Regulatory Element Binding ProteinsTriterpenesbetulincardiomyopathyChagas diseaseendoplasmic reticulum stressmitochondrial stressSREBP activation

Identifiers

PMID31973605
PMCPMC7033903
OpenAlexW3002064442

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.