Evidence map›Paper›PMID 31973579›Full record

ArticleBiological research for nursing2020

Oxidative Stress Biomarker Decreased in Preterm Neonates Treated With Kangaroo Mother Care.

Dorothy Forde, Douglas D Deming, John C Tan, Raylene M Phillips, Eileen K Fry-Bowers, Mary K Barger, Khaled Bahjri, Danilyn M Angeles, Danilo S Boskovic

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological research for nursing, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 4 pooled it
2.2field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. Observational
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. NICU sensory experiences associated with positive outcomes: an integrative review of evidence from 2015-2020.Journal of perinatology : official journal of the California Perinatal Association · 2023
    Review
  15. Article
  16. Oxidative Stress in Preterm Newborns.Antioxidants (Basel, Switzerland) · 2021
    Review
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Dorothy FordeHahn School of Nursing, University of San Diego, CA, USA.ORCID 0000-0001-8016-2955
Douglas D DemingDepartment of Pediatrics, Division of Neonatology, School of Medicine, Loma Linda University, Loma, CA, USA.
John C TanDepartment of Basic Sciences, Division of Biomedical Engineering Sciences, School of Medicine, Loma Linda University, Loma Linda, CA, USA.
Raylene M PhillipsDepartment of Pediatrics, Division of Neonatology, School of Medicine, Loma Linda University, Loma, CA, USA.
Eileen K Fry-BowersHahn School of Nursing, University of San Diego, CA, USA.
Mary K BargerHahn School of Nursing, University of San Diego, CA, USA.
Khaled BahjriSchool of Pharmacy, Loma Linda University, Loma Linda, CA, USA.
Danilyn M AngelesDepartment of Pediatrics, Division of Neonatology, School of Medicine, Loma Linda University, Loma, CA, USA.
Danilo S BoskovicDepartment of Basic Sciences, Division of Biochemistry, School of Medicine, Loma Linda University, Loma Linda, CA, USA.ORCID 0000-0001-6919-3726
Loma Linda University · USUniversity of San Diego · US

Funding

Pain and Hypoxia in Premature NeonatesR01NR011209 · NINR · LOMA LINDA UNIVERSITY · PI ANGELES, DANILYN MAG-AKAT · 2009 to 2017
$2.9M
Biobehavioral Research Training Program in Symptom ScienceT32NR016920 · NINR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MIASKOWSKI, CHRISTINE A., WEISS, SANDRA JEAN · 2017 to 2021
$2.4M
NINR NIH HHS R01 NR011209NINR NIH HHS T32 NR016920
6 · The paper itself

Abstract

objectiveDue to physiological and metabolic immaturity, prematurely born infants are at increased risk because of maternal separation in many neonatal intensive care units (NICUs). The stress induced from maternal-infant separation can lead to well-documented short-term physiologic instability and potentially lifelong neurological, sociological, or psychological sequelae. Based on previous studies of kangaroo mother care (KMC) that demonstrated improvement in physiologic parameters, we examined the impact of KMC on physiologic measures of stress (abdominal temperature, heart rate, oxygen saturation, perfusion index, near-infrared spectrometry), oxidative stress, and energy utilization/conservation in preterm infants.

methodsIn this randomized, stratified study of premature neonates, we compared the effects on urinary concentrations of biomarkers of energy utilization and oxidative stress of 1 hr of KMC versus incubator care on Day 3 of life in intervention-group babies (

resultsMean allantoin levels over Days 3 and 4 were significantly lower in the KMC group than in the control group (

conclusionsResults provide preliminary evidence that KMC reduces neonatal oxidative stress processes and that urinary allantoin could serve as an effective noninvasive marker for future studies.

Indexed as

Kangaroo-Mother Care MethodMother-Child RelationsAdultBiomarkersFemaleHumansInfantInfant, Low Birth WeightInfant, NewbornInfant, PrematureInfant, Premature, DiseasesIntensive Care Units, NeonatalMaleOxidative StressBiomarkersallantoinbiochemical markerhypoxanthinekangaroo mother careuric acidxanthine

Identifiers

PMID31973579
PMCPMC7273802
OpenAlexW3001356191

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.