Observational studyAmerican journal of respiratory and critical care medicine2020
Lung Microbiota Predict Clinical Outcomes in Critically Ill Patients.
2 registry-linked trialsOpen access · greenAbstract readObservational Study
In one paragraph
Observational study in American journal of respiratory and critical care medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 228 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
228citing papers in PubMed, 2 pooled it
5.3field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigating the Inflammatory Cytokines and Cytokine Storm Among Bangladeshi Patients With COVID-19: a Prospective, Observational Study
"Pulmonary Microbiota and Related Immunity Role in Predicting Ventilator Associated- Pneumonia (VAP) Development in Mechanical Ventilated Patients"
Who cites it
228 citing papers in PubMed, 2 syntheses or guidelines pooled it, 354 citations in OpenAlex.
- Early-Life Gut Microbiota and the Pediatric Gut-Lung Axis: A Systematic Review of Clinical, Preclinical, and Mechanistic Evidence.Nutrients · 2026Pooled it
- Composition and diversity of the pulmonary microbiome in acute respiratory distress syndrome: a systematic review.Critical care (London, England) · 2025Pooled it
- Airway microbial compartmentalization under mechanical ventilation: a randomized pilot study comparing an endotracheal tube with suction and continuous cuff pressure control (Venner PneuXRespiratory research · 2026Trial
- Autologous Cord Blood Mononuclear Cells Modulate Immunity and the Microbiota in Very Preterm Twins: A Randomized Trial.Stem cell reviews and reports · 2026Trial
- Modifications of lung microbiota structure in traumatic brain injury ventilated patients according to time and enteral feeding formulas: a prospective randomized study.Critical care (London, England) · 2023Trial
- ICU-acquired pneumonia beyond pathogen detection.Nature communications · 2026Review
- The role of the respiratory microbiome in acute and chronic respiratory diseases.Nature reviews. Microbiology · 2026Review
- Analysis of the pulmonary microbiome in ARDS patients using bronchoalveolar lavage fluid metagenomic next-generation sequencing: a retrospective observational study.Journal of intensive care · 2026Article
- Pleiotropic modulation of the gut-brain-lung axis by ketamine and its enantiomers.Molecular psychiatry · 2026Review
- Mitochondria Meet the Lung Microbiome: A Bidirectional Dialogue in Inflammation and Respiratory Diseases.Biomedicines · 2026Review
- Metagenomic-based quantification of Pseudomonas aeruginosa burden links microbiome collapse to mortality in severe community-acquired pneumonia.Annals of clinical microbiology and antimicrobials · 2026Article
- Microbiota-Immune Crosstalk in Pneumonia and Acute Lung Injury: Mechanisms, Evidence, and Therapeutic Opportunities.Microorganisms · 2026Review
- Blood mNGS: an effective non-invasive diagnostic tool for Pneumocystis jirovecii pneumonia.BMC microbiology · 2026Article
- The molecular ICU: a primer on omics, informatics and the future of precision critical care.Critical care (London, England) · 2026Review
- Gut Hi-C metagenomes of severe COVID-19 patients: bacteria and yeast involved in gut-lung axis.mSphere · 2026Article
- The diagnostic and prognostic utility of blood metagenomic next-generation sequencing for invasive pulmonary aspergillosis.Microbiology spectrum · 2026Article
- The Role of the Respiratory Microbiome in Pneumonia.Clinics in chest medicine · 2026Review
- The gut-lung axis in ARDS: beyond microbial translocation.Respiratory research · 2026Review
- Article
- Current Insights into Clinical, Molecular, and Therapeutic Approaches to Acute Respiratory Distress Syndrome.Medical sciences (Basel, Switzerland) · 2026Review
168 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
12 authors at 6 institutions in 4 countries.
Robert P DicksonDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine.ORCID 0000-0002-6875-4277
Marcus J SchultzIntensive Care.
Tom van der PollCentre for Experimental and Molecular Medicine and.
Laura R SchoutenIntensive Care.
Nicole R FalkowskiDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine.
Jenna E LuthDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine.
Michael W SjodingDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine.
Christopher A BrownDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine.
Rishi ChanderrajDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine.
Gary B HuffnagleDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine.
Lieuwe D J BosIntensive Care.
Biomarker Analysis in Septic ICU Patients (BASIC) Consortium
Pulmonary and Critical Care Associates · USAmsterdam University Medical Centers · NLCentre of Experimental Medicine of the Slovak Academy of Sciences · SKMahidol University · THUniversity of Amsterdam · NLUniversity of Michigan · US
Funding
PULMONARY CELLULAR AND MOLECULAR BIOLOGY TRAININGT32HL007749 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Robert Pickett Dickson · 1993 to 2026
$19.9MThe role of the lung microbiome in oxygen-induced lung injuryR01HL144599 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DICKSON, ROBERT PICKETT · 2019 to 2023
$2.1MData-Driven Identification of the Acute Respiratory Distress SyndromeK01HL136687 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SJODING, MICHAEL WILLIAM · 2017 to 2021
$862kThe Role of the Microbiome in the Acute Respiratory Distress SyndromeK23HL130641 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DICKSON, ROBERT PICKETT · 2016 to 2020
$859kRapid pathogen identification in pneumonia using real-time metagenomics and ultrasensitive PCRR21AI137669 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DICKSON, ROBERT PICKETT · 2018 to 2019
$429kNHLBI NIH HHS K01 HL136687NHLBI NIH HHS K23 HL130641NHLBI NIH HHS R01 HL144599NHLBI NIH HHS T32 HL007749NIAID NIH HHS R21 AI137669
Abstract
PubMed holds no abstract for this paper.
Indexed as
AdultAgedBacterial LoadBronchoalveolar Lavage FluidCohort StudiesCritical IllnessEnterobacteriaceaeEubacterialesFemaleGastrointestinal MicrobiomeHumansLungMaleMicrobiotaMiddle AgedPasteurellaceaeRNA, Ribosomal, 16Sacute respiratory distress syndromelung injurylung microbiomeprognosis
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT04598334ClinicalTrials.gov
NCT04849039ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.