Evidence map›Paper›PMID 31973150›Full record

ArticleVaccines2020

Co-Administration of Injected and Oral Vaccine Candidates Elicits Improved Immune Responses over Either Route Alone.

Celine A Hayden, Danilo Landrock, Chiung Yu Hung, Gary Ostroff, Gina M Fake, John H Walker, Ann Kier, John A Howard

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. From soil to clinic: current advances in understandingMicrobiology and molecular biology reviews : MMBR · 2024
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Celine A HaydenApplied Biotechnology Institute, Cal Poly Tech Park, San Luis Obispo, CA 93407, USA.
Danilo LandrockDepartment of Veterinary Pathobiology, College of Veterinary Medicine, Texas A & M University, College Station, TX 77843, USA.
Chiung Yu HungDepartment of Biology, University of Texas San Antonio, One UTSA Circle, San Antonio, TX 78249, USA.
Gary OstroffProgram in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation St. Biotech 2, Suite 113, Worcester, MA 01605, USA.
Gina M FakeApplied Biotechnology Institute, Cal Poly Tech Park, San Luis Obispo, CA 93407, USA.
John H WalkerDepartment of Statistics, California Polytechnic State University, San Luis Obispo, CA 93407, USA.
Ann KierDepartment of Veterinary Pathobiology, College of Veterinary Medicine, Texas A & M University, College Station, TX 77843, USA.
John A HowardApplied Biotechnology Institute, Cal Poly Tech Park, San Luis Obispo, CA 93407, USA.
Applied Biotechnology Institute · USCalifornia Polytechnic State University · USTexas A&M University · USThe University of Texas at San Antonio · USUniversity of Massachusetts Chan Medical School · US

Funding

Development of a multivalent vaccine against Coccidioides infectionR01AI135005 · NIAID · UNIVERSITY OF TEXAS SAN ANTONIO · PI HUNG, CHIUNG-YU · 2018 to 2022
$1.9M
NIAID NIH HHS R01 AI135005NIH HHS 2R44DK109746NIH HHS HHSN272201600035C
6 · The paper itself

Abstract

Infectious diseases continue to be a significant cause of morbidity and mortality, and although efficacious vaccines are available for many diseases, some parenteral vaccines elicit little or no mucosal antibodies which can be a significant problem since mucosal tissue is the point of entry for 90% of pathogens. In order to provide protection for both serum and mucosal areas, we have tested a combinatorial approach of both parenteral and oral administration of antigens for diseases caused by a viral pathogen, Hepatitis B, and a fungal pathogen,

Indexed as

bioencapsulationimmunogenicitymaize oral vaccinemucosalplant vaccinesubunit vaccinesupercritical fluid extraction

Identifiers

PMID31973150
PMCPMC7157212
OpenAlexW3002756398

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.