Evidence map›Paper›PMID 31973020›Full record

ReviewInternational journal of environmental research and public health2020

Nickel: Human Health and Environmental Toxicology.

Giuseppe Genchi, Alessia Carocci, Graziantonio Lauria, Maria Stefania Sinicropi, Alessia Catalano

Open access · goldAbstract readReview
In one paragraph

Review in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 345 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
345citing papers in PubMed, 2 pooled it
71.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

345 citing papers in PubMed, 2 syntheses or guidelines pooled it, 1,458 citations in OpenAlex.

  1. Pooled it
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  17. Application of FeBMC plant biology · 2026
    Article
  18. Element-specific global burden of cancers attributable to occupational metals (As, Be, Cd, Cr, Ni), 1990-2021: trends, SDI-linked inequalities, and explainable forecasting to 2030.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
  19. Article
  20. Co-exposure to arsenic and nickel induces oxidative stress and mineral imbalance, impairing male reproductive parameters in Wistar rats.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Article

285 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Giuseppe GenchiDipartimento di Farmacia e Scienze della Salute e della Nutrizione, Università della Calabria, 87036 Arcavacata di Rende (Cosenza), Italy.
Alessia CarocciDipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari "A. Moro", 70125 Bari, Italy.
Graziantonio LauriaDipartimento di Farmacia e Scienze della Salute e della Nutrizione, Università della Calabria, 87036 Arcavacata di Rende (Cosenza), Italy.
Maria Stefania SinicropiDipartimento di Farmacia e Scienze della Salute e della Nutrizione, Università della Calabria, 87036 Arcavacata di Rende (Cosenza), Italy.
Alessia CatalanoDipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari "A. Moro", 70125 Bari, Italy.
University of Calabria · ITUniversity of Bari Aldo Moro · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nickel is a transition element extensively distributed in the environment, air, water, and soil. It may derive from natural sources and anthropogenic activity. Although nickel is ubiquitous in the environment, its functional role as a trace element for animals and human beings has not been yet recognized. Environmental pollution from nickel may be due to industry, the use of liquid and solid fuels, as well as municipal and industrial waste. Nickel contact can cause a variety of side effects on human health, such as allergy, cardiovascular and kidney diseases, lung fibrosis, lung and nasal cancer. Although the molecular mechanisms of nickel-induced toxicity are not yet clear, mitochondrial dysfunctions and oxidative stress are thought to have a primary and crucial role in the toxicity of this metal. Recently, researchers, trying to characterize the capability of nickel to induce cancer, have found out that epigenetic alterations induced by nickel exposure can perturb the genome. The purpose of this review is to describe the chemical features of nickel in human beings and the mechanisms of its toxicity. Furthermore, the attention is focused on strategies to remove nickel from the environment, such as phytoremediation and phytomining.

Indexed as

Environmental HealthNickelSoil PollutantsAnimalsBiodegradation, EnvironmentalEcotoxicologyHumansIndustrial WasteIndustrial WasteNickelSoil Pollutantsapoptosisepigeneticsnickelnickel allergynickel phytoremediationnickel toxicity

Identifiers

PMID31973020
PMCPMC7037090
OpenAlexW3001369673

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.