Evidence map›Paper›PMID 31972957›Full record

ReviewJournal of clinical medicine2020

Screening Readthrough Compounds to Suppress Nonsense Mutations: Possible Application to β-Thalassemia.

Monica Borgatti, Emiliano Altamura, Francesca Salvatori, Elisabetta D'Aversa, Nicola Altamura

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. The Involvement ofBiology · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. En route towards a personalized medicine approach: Innovative therapeutic modalities for connective tissue disorders.Matrix biology : journal of the International Society for Matrix Biology · 2023
    Review
  10. Article
  11. Inhibition of Nonsense-Mediated Decay Induces Nociceptive Sensitization through Activation of the Integrated Stress Response.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  12. Review
  13. Current Strategies of Muscular Dystrophy Therapeutics: An Overview.Methods in molecular biology (Clifton, N.J.) · 2023
    Review
  14. Article
  15. Article
  16. Functional Restoration ofFrontiers in pharmacology · 2022
    Article
  17. Nonsense suppression therapies in human genetic diseases.Cellular and molecular life sciences : CMLS · 2021
    Review
  18. Article
  19. Ataluren and aminoglycosides stimulate read-through of nonsense codons by orthogonal mechanisms.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Monica BorgattiBiotechnology Center, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0001-8470-2496
Emiliano AltamuraChemistry Department, University of Bari, 70126 Bari, Italy.ORCID 0000-0003-3171-6645
Francesca SalvatoriBiotechnology Center, University of Ferrara, 44121 Ferrara, Italy.
Elisabetta D'AversaBiotechnology Center, University of Ferrara, 44121 Ferrara, Italy.
Nicola AltamuraInstitute of Biomembranes, Bioenergetics and Molecular Biotechnologies, National Researches Council, 70126 Bari, Italy.
University of Ferrara · ITInstitute of Biomembranes, Bioenergetics and Molecular Biotechnologies · ITUniversity of Bari Aldo Moro · IT

Funding

Agenzia Italiana del Farmaco, Ministero della Salute AIFA-2016-02364887FP7-HEALTH-2012 306201Wellcome Trust Innovator Award 208872/Z/17/Z
6 · The paper itself

Abstract

Several types of thalassemia (including β

Indexed as

nonsense mediated mRNA decaynonsense suppressionpremature termination codonreadthrough moleculesβ0-thalassemia

Identifiers

PMID31972957
PMCPMC7073686
OpenAlexW3000611104

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.