Evidence map›Paper›PMID 31972558›Full record

ReviewBiofabrication2020

Assessment methodologies for extrusion-based bioink printability.

Gregory Gillispie, Peter Prim, Joshua Copus, John Fisher, Antonios G Mikos, James J Yoo, Anthony Atala, Sang Jin Lee

Abstract readReview
In one paragraph

Review in Biofabrication, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 139 papers.

0numbers the graph read from it
0cells of the map it votes in
139citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

139 citing papers in PubMed.

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  14. Beyond graphene: the MXene era in bioprinting.Biomedical engineering online · 2026
    Review
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79 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gregory GillispieWake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC, United States of America.ORCID 0000-0002-0929-846X
Peter PrimWake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC, United States of America.
Joshua CopusWake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC, United States of America.
John FisherFischell Department of Bioengineering, University of Maryland, College Park, MD, United States of America.
Antonios G MikosDepartments of Bioengineering and Chemical and Biomolecular Engineering, Rice University, Houston, TX, United States of America.ORCID 0000-0002-0709-990X
James J YooWake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC, United States of America.
Anthony AtalaWake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC, United States of America.
Sang Jin LeeWake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC, United States of America.ORCID 0000-0002-3899-1909

Funding

Training and Dissemination CoreP41EB023833 · NIBIB · UNIV OF MARYLAND, COLLEGE PARK · PI MIKOS, ANTONIOS G. · 2017 to 2021
$6.2M
NIBIB NIH HHS P41 EB023833
6 · The paper itself

Abstract

Extrusion-based bioprinting is one of the leading manufacturing techniques for tissue engineering and regenerative medicine. Its primary limitation is the lack of materials, known as bioinks, which are suitable for the bioprinting process. The degree to which a bioink is suitable for bioprinting has been described as its 'printability.' However, a lack of clarity surrounding the methodologies used to evaluate a bioink's printability, as well as the usage of the term itself, have hindered the field. This article presents a review of measures used to assess the printability of extrusion-based bioinks in an attempt to assist researchers during the bioink development process. Many different aspects of printability exist and many different measurements have been proposed as a consequence. Researchers often do not evaluate a new bioink's printability at all, while others simply do so qualitatively. Several quantitative measures have been presented for the extrudability, shape fidelity, and printing accuracy of bioinks. Different measures have been developed even within these aspects, each testing the bioink in a slightly different way. Additionally, other relevant measures which had little or no examples of quantifiable methods are also to be considered. Looking forward, further work is needed to improve upon current assessment methodologies, to move towards a more comprehensive view of printability, and to standardize these printability measurements between researchers. Better assessment techniques will naturally lead to a better understanding of the underlying mechanisms which affect printability and better comparisons between bioinks. This in turn will help improve upon the bioink development process and the bioinks available for use in bioprinting.

Indexed as

AnimalsBioprintingHumansPrinting, Three-DimensionalTissue EngineeringTissue Scaffolds

Identifiers

PMID31972558
PMCPMC7039534

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.