Evidence map›Paper›PMID 31972514›Full record

ArticleiScience2020

Δ-Tetrahydrocannabinol Increases Dopamine D1-D2 Receptor Heteromer and Elicits Phenotypic Reprogramming in Adult Primate Striatal Neurons.

Ahmed Hasbi, Bertha K Madras, Jack Bergman, Stephen Kohut, Zhicheng Lin, Sarah L Withey, Susan R George

Open access · goldAbstract read
In one paragraph

Article in iScience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. G Protein-Coupled Receptor Dimerization-What Next?International journal of molecular sciences · 2024
    Review
  3. Tetrahydrocannabinol and dopamine D1 receptor.Frontiers in neuroscience · 2024
    Review
  4. Article
  5. Daily ΔBiological psychiatry global open science · 2023
    Article
  6. Controlled human drug administration studies are necessary to define the THC-sparing effects of CBD and other cannabis constituents.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Effects of daily ΔDrug and alcohol dependence · 2021
    Article
  14. NOX1/NADPH Oxidase Promotes Synaptic Facilitation Induced by Repeated DThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Ahmed HasbiDepartment of Pharmacology, University of Toronto, Toronto, ON, Canada.
Bertha K MadrasDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA; McLean Hospital, Belmont, USA.
Jack BergmanDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA; McLean Hospital, Belmont, USA.
Stephen KohutDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA; McLean Hospital, Belmont, USA.
Zhicheng LinDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA; McLean Hospital, Belmont, USA.
Sarah L WitheyDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA; McLean Hospital, Belmont, USA.
Susan R GeorgeDepartment of Pharmacology, University of Toronto, Toronto, ON, Canada; Department of Medicine, University of Toronto, Toronto, ON, Canada. Electronic address: s.george@utoronto.ca.
Harvard University · USUniversity of Toronto · CAMcLean Hospital · US

Funding

Long Term THC Elicits Distinct Changes in Adolescent Brain Dopamine SignalingR01DA042178 · NIDA · MCLEAN HOSPITAL · PI MADRAS, BERTHA K · 2017 to 2021
$2.8M
NIDA NIH HHS R01 DA042178
6 · The paper itself

Abstract

Long-term cannabis users manifest deficits in dopaminergic functions, reflecting Δ

Indexed as

Cellular NeuroscienceDrugsNeuroscience

Identifiers

PMID31972514
PMCPMC6971351
OpenAlexW2997116186

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.