Evidence map›Paper›PMID 31972507›Full record

ArticleRedox biology2020

Indoxyl sulfate impairs valsartan-induced neovascularization.

Ko-Lin Kuo, Jin-Feng Zhao, Po-Hsun Huang, Bei-Chia Guo, Der-Cherng Tarng, Tzong-Shyuan Lee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Ko-Lin KuoDivision of Nephrology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan; School of Medicine, Buddhist Tzu Chi University, Hualien, Taiwan.
Jin-Feng ZhaoMRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, UK.
Po-Hsun HuangInstitutes of Clinical Medicine, Taipei, Taiwan; Cardiovascular Research Center, School of Medicine, National Yang-Ming University, Taipei, Taiwan; Divisions of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Bei-Chia GuoGraduate Institute and Department of Physiology, College of Medicine, National Taiwan University, Taipei, 10051, Taiwan.
Der-Cherng TarngInstitutes of Clinical Medicine, Taipei, Taiwan; Department and Institute of Physiology, National Yang-Ming University, Taipei, Taiwan; Division of Nephrology, Department of Medicine and Immunology Research Centre, Taipei Veterans General Hospital, Taipei, Taiwan. Electronic address: dctarng@vghtpe.gov.tw.
Tzong-Shyuan LeeGraduate Institute and Department of Physiology, College of Medicine, National Taiwan University, Taipei, 10051, Taiwan. Electronic address: ntutslee@ntu.edu.tw.
National Taiwan University · TWTaipei Institute of Pathology · TWTaipei Veterans General Hospital · TWTzu Chi University · TWUniversity of Dundee · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Studies revealed that the use of renin-angiotensin-aldosterone system antagonism is not associated with a statistically significant reduction in the risk of cardiovascular events in patients with chronic kidney disease (CKD) compared with that in the general population. We tested the hypothesis that indoxyl sulfate (IS) can interfere with the protective effect of valsartan-mediated on endothelial function in vitro and neovascularization in mice underwent subtotal nephrectomy. In human aortic endothelial cells, we first demonstrated that IS impaired the valsartan-mediated phosphorylation of eNOS

Indexed as

AnimalsCell LineDisease Models, AnimalHindlimbHumansIndicanIschemiaMaleMiceNeovascularization, PhysiologicNephrectomyNitric OxideNitric Oxide Synthase Type IIIPhosphorylationPlatelet Endothelial Cell Adhesion Molecule-1Protein Kinase C-alphaIndicanNitric OxideNitric Oxide Synthase Type IIINos3 protein, mousePlatelet Endothelial Cell Adhesion Molecule-1Prkca protein, mouseProtein Kinase C-alphaValsartanChronic kidney diseaseIndoxyl sulfateNeovascularizationValsartan

Identifiers

PMID31972507
PMCPMC6974788
OpenAlexW2999844378

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.