Evidence map›Paper›PMID 31972397›Full record

Trial reportNeuroImage. Clinical2020

Creative music therapy to promote brain function and brain structure in preterm infants: A randomized controlled pilot study.

Friederike Barbara Haslbeck, Andras Jakab, Ulrike Held, Dirk Bassler, Hans-Ulrich Bucher, Cornelia Hagmann

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in NeuroImage. Clinical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 4 pooled it
23.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 4 syntheses or guidelines pooled it, 122 citations in OpenAlex.

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  8. Music Therapy in Preterm Infants Reduces Maternal Distress.International journal of environmental research and public health · 2022
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  9. Music Therapy Is Effective during Sleep in Preterm Infants.International journal of environmental research and public health · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Friederike Barbara HaslbeckDepartment of Neonatology, University Hospital Zurich and University Zurich, Frauenklinikstrasse 10, 8091 Zürich, Switzerland. Electronic address: friederike.haslbeck@usz.ch.
Andras JakabMR Research Center, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032 Zürich, Switzerland.
Ulrike HeldDepartment of Biostatistics Epidemiology, Biostatistics and Prevention Institute UZH, Hirschengraben 84, 8001 Zürich, Switzerland.
Dirk BasslerDepartment of Neonatology, University Hospital Zurich and University Zurich, Frauenklinikstrasse 10, 8091 Zürich, Switzerland.
Hans-Ulrich BucherDepartment of Neonatology, University Hospital Zurich and University Zurich, Frauenklinikstrasse 10, 8091 Zürich, Switzerland.
Cornelia HagmannDepartment of Neonatology and Pediatric Intensive Care, Children's University Hospital of Zurich, Steinwiesstrasse 75, 8032 Zürich, Switzerland; Children's Research Center, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032 Zürich, Switzerland.
University Hospital of Zurich · CHUniversity Children's Hospital Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cognitive and neurobehavioral problems are among the most severe adverse outcomes in very preterm infants. Such neurodevelopmental impairments may be mitigated through nonpharmacological interventions such as creative music therapy (CMT), an interactive, resource- and needs-oriented approach that provides individual social contact and musical stimulation. The aim was to test the feasibility of a study investigating the role of CMT and to measure the short- and medium-term effects of CMT on structural and functional brain connectivity with MRI. In this randomized, controlled clinical pilot feasibility trial, 82 infants were randomized to either CMT or standard care. A specially trained music therapist provided CMT via infant-directed humming and singing in lullaby style. To test the short-term effects of CMT on brain structure and function, diffusion tensor imaging data and resting-state functional imaging data were acquired. Clinical feasibility was achieved despite moderate parental refusal mainly in the control group after randomization. 40 infants remained as final cohort for the MRI analysis. Structural brain connectivity appears to be moderately affected by CMT, structural connectomic analysis revealed increased integration in the posterior cingulate cortex only. Lagged resting-state MRI analysis showed lower thalamocortical processing delay, stronger functional networks, and higher functional integration in predominantly left prefrontal, supplementary motor, and inferior temporal brain regions in infants treated with CMT. This trial provides unique evidence that CMT has beneficial effects on functional brain activity and connectivity in networks underlying higher-order cognitive, socio-emotional, and motor functions in preterm infants. Our results indicate the potential of CMT to improve long-term neurodevelopmental outcomes in children born very preterm.

Indexed as

Cerebral CortexConnectomeDiffusion Tensor ImagingInfant, PrematureMusic TherapyNerve NetThalamusFeasibility StudiesHumansInfant, Extremely PrematureInfant, NewbornPilot ProjectsProspective StudiesFunctional connectivityMusic therapyNeurodevelopmentPreterm infantsResting state fMRIThalamocortical processing

Identifiers

PMID31972397
PMCPMC6974781
OpenAlexW2999887837

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.