ArticleNeuroImage2020
Striatal iron content is linked to reduced fronto-striatal brain function under working memory load.
Article in NeuroImage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Translation of task-evoked negative BOLD response into aging and Alzheimer's disease: a systematic review of the current literature.Journal of translational medicine · 2025Pooled it
- Pooled it
- Quantitative susceptibility mapping demonstrates ageing-related long-term structural brain changes in adult rats after mild ischaemic stroke.Brain communications · 2026Article
- Association of Increased Brain Iron Levels With Anxiety and Motor Dysfunction in Cerebral Small Vessel Disease.CNS neuroscience & therapeutics · 2025Article
- Article
- Exploring the links among brain iron accumulation, cognitive performance, and dietary intake in older adults: A longitudinal MRI study.Neurobiology of aging · 2025Article
- A Review of the Association Between Dietary Intake and Brain Iron Levels in Older Adults: Preliminary Findings and Future Directions.Nutrients · 2024Review
- Inflammation in Metal-Induced Neurological Disorders and Neurodegenerative Diseases.Biological trace element research · 2024Review
- Automated segmentation of midbrain nuclei using deep learning and multisequence MRI: A longitudinal study on iron accumulation with age.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- High cortical iron is associated with the disruption of white matter tracts supporting cognitive function in healthy older adults.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Association between iron accumulation in the dorsal striatum and compulsive drinking in alcohol use disorder.Psychopharmacology · 2023Article
- Cognition and brain iron deposition in whole grey matter regions and hippocampal subfields.The European journal of neuroscience · 2022Article
- Learning to read Chinese promotes two cortico-subcortical pathways: The development of thalamo-occipital and fronto-striatal circuits.Frontiers in neuroscience · 2022Article
- Healthy dietary intake moderates the effects of age on brain iron concentration and working memory performance.Neurobiology of aging · 2021Article
- Neuroimaging, Urinary, and Plasma Biomarkers of Treatment Response in Huntington's Disease: Preclinical Evidence with the p75Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Article
- Attenuated cerebral blood flow in frontolimbic and insular cortices in Alcohol Use Disorder: Relation to working memory.Journal of psychiatric research · 2021Article
- Implicit associative learning relates to basal ganglia gray matter microstructure in young and older adults.Behavioural brain research · 2021Article
- Greater BOLD Variability is Associated With Poorer Cognitive Function in an Adult Lifespan Sample.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Non-heme iron accumulation contributes to age-related decline in brain structure and cognition via a cascade of oxidative stress and inflammation, although its effect on brain function is largely unexplored. Thus, we examine the impact of striatal iron on dynamic range of BOLD modulation to working memory load. N = 166 healthy adults (age 20-94) underwent cognitive testing and an imaging session including n-back (0-, 2-, 3-, and 4-back fMRI), R2*-weighted imaging, and pcASL to measure cerebral blood flow. A statistical model was constructed to predict voxelwise BOLD modulation by age, striatal iron content and an age × iron interaction, controlling for cerebral blood flow, sex, and task response time. A significant interaction between age and striatal iron content on BOLD modulation was found selectively in the putamen, caudate, and inferior frontal gyrus. Greater iron was associated with reduced modulation to difficulty, particularly in middle-aged and younger adults with greater iron content. Further, iron-related decreases in modulation were associated with poorer executive function in an age-dependent manner. These results suggest that iron may contribute to differences in functional brain activation prior to older adulthood, highlighting the potential role of iron as an early factor contributing to trajectories of functional brain aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.