Evidence map›Paper›PMID 31972058›Full record

ReviewYeast (Chichester, England)2020

Vitamin requirements and biosynthesis in Saccharomyces cerevisiae.

Thomas Perli, Anna K Wronska, Raúl A Ortiz-Merino, Jack T Pronk, Jean-Marc Daran

Open access · bronzeAbstract readReview
In one paragraph

Review in Yeast (Chichester, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 1 synthesis or guideline pooled it, 141 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Thomas PerliDepartment of Biotechnology, Delft University of Technology, Delft, The Netherlands.ORCID 0000-0002-4910-3292
Anna K WronskaDepartment of Biotechnology, Delft University of Technology, Delft, The Netherlands.ORCID 0000-0002-6103-3039
Raúl A Ortiz-MerinoDepartment of Biotechnology, Delft University of Technology, Delft, The Netherlands.ORCID 0000-0003-4186-8941
Jack T PronkDepartment of Biotechnology, Delft University of Technology, Delft, The Netherlands.ORCID 0000-0002-5617-4611
Jean-Marc DaranDepartment of Biotechnology, Delft University of Technology, Delft, The Netherlands.ORCID 0000-0003-3136-8193
Delft University of Technology · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemically defined media for yeast cultivation (CDMY) were developed to support fast growth, experimental reproducibility, and quantitative analysis of growth rates and biomass yields. In addition to mineral salts and a carbon substrate, popular CDMYs contain seven to nine B-group vitamins, which are either enzyme cofactors or precursors for their synthesis. Despite the widespread use of CDMY in fundamental and applied yeast research, the relation of their design and composition to the actual vitamin requirements of yeasts has not been subjected to critical review since their first development in the 1940s. Vitamins are formally defined as essential organic molecules that cannot be synthesized by an organism. In yeast physiology, use of the term "vitamin" is primarily based on essentiality for humans, but the genome of the Saccharomyces cerevisiae reference strain S288C harbours most of the structural genes required for synthesis of the vitamins included in popular CDMY. Here, we review the biochemistry and genetics of the biosynthesis of these compounds by S. cerevisiae and, based on a comparative genomics analysis, assess the diversity within the Saccharomyces genus with respect to vitamin prototrophy.

Indexed as

BiomassBiotinInositolNiacinPantothenic AcidPyridoxineReproducibility of ResultsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsThiamineVitaminsBiotinInositolNiacinPantothenic AcidPyridoxineSaccharomyces cerevisiae ProteinsThiamineVitaminsfermentationgrowth requirementsSaccharomyces cerevisiaesynthetic mediavitamin biosynthesis

Identifiers

PMID31972058
PMCPMC7187267
OpenAlexW3002316566

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.