ArticleCancer2020
Prediagnosis social support, social integration, living status, and colorectal cancer mortality in postmenopausal women from the women's health initiative.
Article in Cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Living alone and mortality risk in cancer patients: a systematic review and meta-analysis.Frontiers in oncology · 2026Pooled it
- Loneliness, social isolation, and living alone: a comprehensive systematic review, meta-analysis, and meta-regression of mortality risks in older adults.Aging clinical and experimental research · 2025Pooled it
- A systematic review and meta-analysis of 90 cohort studies of social isolation, loneliness and mortality.Nature human behaviour · 2023Pooled it
- Marital Status Is Associated With Treatment Attainment in Pancreatic Adenocarcinoma.Journal of surgical oncology · 2026Article
- A Network Analysis of Social Integration and Subjective Well-Being in Young and Middle-Aged Lymphoma Patients.Patient preference and adherence · 2026Article
- Development and Validation of a Natural Language Processing Algorithm Using Electronic Health Record Data to Identify Breast Cancer Patients With Low Social Support.JCO oncology advances · 2025Article
- Mental Comorbidity and Psychosocial Care in Patients with Cancer.Deutsches Arzteblatt international · 2025Article
- Influence of Primary Care Physicians on End-of-Life Treatment Choices in Lung Cancer Diagnosed in the Emergency Department.Journal of personalized medicine · 2025Article
- Developing, implementing, and disseminating best practices for enhanced collection of sexual orientation and gender identity among cancer patients to catalyze innovative cancer control research.Journal of the National Cancer Institute. Monographs · 2025Article
- Association between prediagnostic risk factors and survival after colorectal cancer diagnosis in Golesten cohort study.Scientific reports · 2025Article
- The mediating roles of family care and self-efficacy between stigma and social alienation among colorectal cancer survivors.Scientific reports · 2025Article
- The association of cancer-related fatigue on the social, vocational and healthcare-related dimensions of cancer survivorship.Journal of cancer survivorship : research and practice · 2025Article
- Social supports in patients with cancer attending an Irish cancer center: a cross-sectional study.The oncologist · 2024Article
- Factors Influencing Social Isolation among Cancer Patients: A Systematic Review.Healthcare (Basel, Switzerland) · 2024Review
- Living Alone, Physical Health, and Mortality in Breast Cancer Survivors: A Prospective Observational Cohort Study.Healthcare (Basel, Switzerland) · 2023Article
- Associations between cancer history, social distancing behaviors, and loneliness in adults during the COVID-19 pandemic.PloS one · 2023Article
- Religiosity, Emotions and Health: The Role of Trust/Mistrust in God in People Affected by Cancer.Healthcare (Basel, Switzerland) · 2022Article
- Early-Onset Colorectal Cancer Survival Differences and Potential Geographic Determinants Among Men and Women in Utah.American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting · 2022Article
- Stress and cancer: mechanisms, significance and future directions.Nature reviews. Cancer · 2021Review
- The Impact of Socioeconomic Risk Factors on the Survival Outcomes of Patients With Newly Diagnosed Multiple Myeloma: A Cross-analysis of a Population-based Registry and a Tertiary Care Center.Clinical lymphoma, myeloma & leukemia · 2021Article
Corrections and comments
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Authors and funding
10 authors at 9 institutions in 1 country.
Funding
Abstract
backgroundWe evaluated associations between perceived social support, social integration, living alone, and colorectal cancer (CRC) outcomes in postmenopausal women.
methodsThe study included 1431 women from the Women's Health Initiative who were diagnosed from 1993 through 2017 with stage I through IV CRC and who responded to the Medical Outcomes Study Social Support survey before their CRC diagnosis. We used proportional hazards regression to evaluate associations of social support (tertiles) and types of support, assessed up to 6 years before diagnosis, with overall and CRC-specific mortality. We also assessed associations of social integration and living alone with outcomes also in a subset of 1141 women who had information available on social ties (marital/partner status, community and religious participation) and living situation.
resultsIn multivariable analyses, women with low (hazard ratio [HR], 1.52; 95% CI, 1.23-1.88) and moderate (HR, 1.21; 95% CI, 0.98-1.50) perceived social support had significantly higher overall mortality than those with high support (P [continuous] < .001). Similarly, women with low (HR, 1.42; 95% CI, 1.07-1.88) and moderate (HR, 1.28; 95% CI, 0.96-1.70) perceived social support had higher CRC mortality than those with high social support (P [continuous] = .007). Emotional, informational, and tangible support and positive interaction were all significantly associated with outcomes, whereas affection was not. In main-effects analyses, the level of social integration was related to overall mortality (P for trend = .02), but not CRC mortality (P for trend = .25), and living alone was not associated with mortality outcomes. However, both the level of social integration and living alone were related to outcomes in patients with rectal cancer.
conclusionsWomen with low perceived social support before diagnosis have higher overall and CRC-specific mortality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.