Evidence map›Paper›PMID 31971998›Full record

ArticleBlood advances2020

Efficacy of combined CDK9/BET inhibition in preclinical models of MLL-rearranged acute leukemia.

Hannah McCalmont, Ka Leung Li, Luke Jones, John Toubia, Sarah C Bray, Debora A Casolari, Chelsea Mayoh, Saumya E Samaraweera, Ian D Lewis, Rab K Prinjha and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Blood advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hannah McCalmontChildren's Cancer Institute, School of Women's and Children's Health, University of New South Wales Sydney, Sydney, NSW, Australia.
Ka Leung LiCentre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, SA, Australia.
Luke JonesChildren's Cancer Institute, School of Women's and Children's Health, University of New South Wales Sydney, Sydney, NSW, Australia.
John ToubiaCentre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, SA, Australia.
Sarah C BrayRegistry of Older South Australians, South Australian Health and Medical Research Institute, Adelaide, SA, Australia.
Debora A CasolariCentre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, SA, Australia.
Chelsea MayohChildren's Cancer Institute, School of Women's and Children's Health, University of New South Wales Sydney, Sydney, NSW, Australia.
Saumya E SamaraweeraCentre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, SA, Australia.
Ian D LewisAdelaide Oncology and Haematology, Adelaide, SA, Australia.
Rab K PrinjhaMedicines Research Centre, GlaxoSmithKline, Stevenage, United Kingdom; and.
Nicholas SmithersMedicines Research Centre, GlaxoSmithKline, Stevenage, United Kingdom; and.
Shudong WangDrug Discovery and Development, Cancer Research Institute, University of South Australia, Adelaide, SA, Australia.
Richard B LockChildren's Cancer Institute, School of Women's and Children's Health, University of New South Wales Sydney, Sydney, NSW, Australia.
Richard J D'AndreaCentre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, SA, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsCyclin-Dependent Kinase 9FemaleHumansLeukemia, Myeloid, AcuteMiceMyeloid-Lymphoid Leukemia ProteinCDK9 protein, humanCyclin-Dependent Kinase 9Myeloid-Lymphoid Leukemia Protein

Identifiers

PMID31971998
PMCPMC6988396

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.