ArticlePLoS pathogens2020
Mobilizable antibiotic resistance genes are present in dust microbial communities.
Article in PLoS pathogens, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Antibiotic Resistance Genes in Dust from Kindergarten Environments: A Systematic Review of Occurrence, Diversity, Determinants, and Exposure Implications.International journal of environmental research and public health · 2026Pooled it
- Metagenomics for antimicrobial resistance: from resistome surveillance to mechanistic inference.Journal of bacteriology · 2026Review
- Recent Microbial Evolutionary Insights From Metagenomics.Genome biology and evolution · 2026Review
- Association of Human Gut Microbiota with Alzheimer's Disease Pathogenesis: An Exploratory Clinical Study.Brain sciences · 2026Article
- Weather conditions structure the taxonomic and functional diversity of the aeolian dust microbiome.Frontiers in microbiology · 2026Article
- Development and application of a triplex ddPCR method for simultaneous detection of MLSB resistance genes in feces and environmental samples.Frontiers in microbiology · 2026Article
- Are Putative Beta-Lactamases Posing a Potential Future Threat?Antibiotics (Basel, Switzerland) · 2025Article
- Microbial landscape of Indian homes: the microbial diversity, pathogens and antimicrobial resistome in urban residential spaces.Environmental microbiome · 2025Article
- House dust-a Pandora's box of antimicrobial resistance (AMR) activity?Sustainable microbiology · 2025Article
- Antibiotic Resistance as a Functional Characteristic of Urban Dust Particles' Microbial Communities.Biology · 2024Article
- Antimicrobial Resistance Elements in Coastal Water of Llanquihue Lake, Chile.Antibiotics (Basel, Switzerland) · 2024Article
- Heterogeneous Antibiotic Resistance Gene Removal Impedes Evaluation of Constructed Wetlands for Effective Greywater Treatment.Antibiotics (Basel, Switzerland) · 2024Article
- Genetic and Phenotypic Characterization ofMicroorganisms · 2024Article
- Commensal antimicrobial resistance mediates microbiome resilience to antibiotic disruption.Science translational medicine · 2024Article
- Insights into the microbiota of raw milk from seven breeds animals distributing in Xinjiang China.Frontiers in microbiology · 2024Article
- Phage communities in household-related biofilms correlate with bacterial hosts.Frontiers in microbiomes · 2024Article
- An improved workflow for accurate and robust healthcare environmental surveillance using metagenomics.Microbiome · 2022Article
- Preclinical Safety Assessment ofMicroorganisms · 2022Article
- The Bacterial Urban Resistome: Recent Advances.Antibiotics (Basel, Switzerland) · 2022Review
- The Human Gut Resistome up to Extreme Longevity.mSphere · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
The decades-long global trend of urbanization has led to a population that spends increasing amounts of time indoors. Exposure to microbes in buildings, and specifically in dust, is thus also increasing, and has been linked to various health outcomes and to antibiotic resistance genes (ARGs). These are most efficiently screened using DNA sequencing, but this method does not determine which microbes are viable, nor does it reveal whether their ARGs can actually disseminate to other microbes. We have thus performed the first study to: 1) examine the potential for ARG dissemination in indoor dust microbial communities, and 2) validate the presence of detected mobile ARGs in viable dust bacteria. Specifically, we integrated 166 dust metagenomes from 43 different buildings. Sequences were assembled, annotated, and screened for potential integrons, transposons, plasmids, and associated ARGs. The same dust samples were further investigated using cultivation and isolate genome and plasmid sequencing. Potential ARGs were detected in dust isolate genomes, and we confirmed their placement on mobile genetic elements using long-read sequencing. We found 183 ARGs, of which 52 were potentially mobile (associated with a putative plasmid, transposon or integron). One dust isolate related to Staphylococcus equorum proved to contain a plasmid carrying an ARG that was detected metagenomically and confirmed through whole genome and plasmid sequencing. This study thus highlights the power of combining cultivation with metagenomics to assess the risk of potentially mobile ARGs for public health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.