ArticlePloS one2020
Embryonic thermal manipulation has short and long-term effects on the development and the physiology of the Japanese quail.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Body surface temperatures as biomarkers of physiological environmental adaptation in wild birds and mammals.Biological reviews of the Cambridge Philosophical Society · 2026Pooled it
- Prenatal acoustic communication triggers adaptive vascular programming in the developing avian brain.The Journal of experimental biology · 2026Article
- Transcriptomic insights into thermal manipulation and heat stress in skeletal muscles of broiler chickens.Poultry science · 2026Article
- Embryonic thermal manipulation enhances splenic immunity and regulates inflammatory responses toFrontiers in veterinary science · 2026Article
- Impact of Thermal Manipulation of Broiler Eggs on Growth Performance, Splenic Inflammatory Cytokine Levels, and Heat Shock Protein Responses to Post-Hatch Lipopolysaccharide (LPS) Challenge.Animals : an open access journal from MDPI · 2025Article
- Light-induced epigenetic modifications in the hypothalamus during avian embryonic development enhance phenotypic plasticity.Frontiers in cell and developmental biology · 2025Article
- Embryonic heat conditioning induces paternal heredity of immunological cross- tolerance: coordinative role of CpG DNA methylation and miR-200a regulation.Frontiers in immunology · 2025Article
- Molecular responses of chicken embryos to maternal heat stress through DNA methylation and gene expression: a pilot study.Environmental epigenetics · 2025Article
- Thermal conditioning of quail embryos has transgenerational and reversible long-term effects.Journal of animal science and biotechnology · 2023Article
- Effects of embryonic thermal manipulation on the immune response to post-hatchVeterinary world · 2023Article
- Effects of Thermal Manipulation on mRNA Regulation of Response Genes Regarding Improvement of Thermotolerance Adaptation in Chickens during Embryogenesis.Animals : an open access journal from MDPI · 2022Review
- Experimental demonstration of prenatal programming of mitochondrial aerobic metabolism lasting until adulthood.Proceedings. Biological sciences · 2022Article
- Chicken embryo as a model in epigenetic research.Poultry science · 2021Review
- Embryonic thermal manipulation impacts the postnatal transcriptome response of heat-challenged Japanese quails.BMC genomics · 2021Article
- Embryonic thermal manipulation of Japanese quail: effects on embryonic development, hatchability, and post-hatch performance.Tropical animal health and production · 2021Article
- Impacts of Embryonic Thermal Programming on the Expression of Genes Involved inFrontiers in physiology · 2021Article
- HSF3 and Hsp70 Expression during Post-Hatch Cold Stress in Broiler Chickens Subjected to Embryonic Thermal Manipulation.Veterinary sciences · 2020Article
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In vertebrates, the embryonic environment is known to affect the development and the health of individuals. In broiler chickens, the thermal-manipulation (TM) of eggs during the incubation period was shown to improve heat tolerance at slaughter age (35 days of age) in association with several modifications at the molecular, metabolic and physiological levels. However, little is known about the Japanese quail (Coturnix japonica), a closely related avian species widely used as a laboratory animal model and farmed for its meat and eggs. Here we developed and characterized a TM procedure (39.5°C and 65% relative humidity, 12 h/d, from days 0 to 13 of incubation) in quails by analyzing its short and long-term effects on zootechnical, physiological and metabolic parameters. Heat-tolerance was tested by a heat challenge (36°C for 7h) at 35 days of age. TM significantly reduced the hatching rate of the animals and increased mortality during the first four weeks of life. At hatching, TM animals were heavier than controls, but lighter at 25 days of age for both sexes. Thirty-five days after hatching, TM decreased the surface temperature of the shank in females, suggesting a modulation of the blood flow to maintain the internal temperature. TM also increased blood partial pressure and oxygen saturation percentage at 35 days of age in females, suggesting a long-term modulation of the respiration physiology. Quails physiologically responded to the heat challenge, with a modification of several hematologic and metabolic parameters, including an increase in plasma corticosterone concentration. Several physiological parameters such as beak surface temperature and blood sodium concentration revealed that TM birds responded differently to the heat challenge compared to controls. Altogether, this first comprehensive characterization of TM in Japanese quail showed durable effects that may affect the response of TM quails to heat.
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