Evidence map›Paper›PMID 31971991›Full record

ArticlePloS one2020

Peer distribution of HIV self-test kits to men who have sex with men to identify undiagnosed HIV infection in Uganda: A pilot study.

Stephen Okoboi, Oucul Lazarus, Barbara Castelnuovo, Mastula Nanfuka, Andrew Kambugu, Andrew Mujugira, Rachel King

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 4 pooled it
1.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 4 syntheses or guidelines pooled it, 85 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Stephen OkoboiInfectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.ORCID 0000-0002-8738-0397
Oucul LazarusThe AIDS Support Organization (TASO), Kampala, Uganda.
Barbara CastelnuovoInfectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.
Mastula NanfukaThe AIDS Support Organization (TASO), Kampala, Uganda.
Andrew KambuguInfectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.
Andrew MujugiraInfectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.
Rachel KingSchool of Public Health, Makerere University, Kampala, Uganda.
Infectious Diseases Institute · UGThe AIDS Support Organization · UGUniversity of California, San Francisco · US

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI Judith Tsui · 1988 to 2026
$104.9M
Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS · 1988 to 2026
$93.6M
HIV Self Testing to Empower Prevention Choices in Sex WorkersK43TW010695 · FIC · INFECTIOUS DISEASES INSTITUTE · PI MUJUGIRA, ANDREW · 2017 to 2021
$530k
FIC NIH HHS K43 TW010695NIAID NIH HHS P30 AI027757NIAID NIH HHS P30 AI027763
6 · The paper itself

Abstract

introductionOne-in-three men who have sex with men (MSM) in Uganda have never tested for HIV. Peer-driven HIV testing strategies could increase testing coverage among non-testers. We evaluated the yield of peer distributed HIV self-test kits compared with standard-of-care testing approaches in identifying undiagnosed HIV infection.

methodsFrom June to August 2018, we conducted a pilot study of secondary distribution of HIV self-testing (HIVST) through MSM peer networks at The AIDS Support Organization (TASO) centres in Entebbe and Masaka. Peers were trained in HIVST use and basic HIV counselling. Each peer distributed 10 HIVST kits in one wave to MSM who had not tested in the previous six months. Participants who tested positive were linked by peers to HIV care. The primary outcome was the proportion of undiagnosed HIV infections. Data were analysed descriptively.

resultsA total of 297 participants were included in the analysis, of whom 150 received HIVST (intervention). The median age of HIVST recipients was 25 years (interquartile range [IQR], 22-28) compared to 28 years IQR (25-35) for 147 MSM tested using standard-of-care (SOC) strategies. One hundred forty-three MSM (95%) completed HIVST, of which 32% had never tested for HIV. A total of 12 participants were newly diagnosed with HIV infection: 8 in the peer HIVST group and 4 in the SOC group [5.6% vs 2.7%, respectively; P = 0.02]. All participants newly diagnosed with HIV infection received confirmatory HIV testing and were initiated on antiretroviral therapy.

conclusionPeer distribution of HIVST through MSM networks is feasible and effective and could diagnose more new HIV infections than SOC approaches. Public health programs should consider scaling up peer-delivered HIVST for MSM.

Indexed as

Peer GroupAdultAnti-HIV AgentsCounselingHIV InfectionsHumansMaleMass ScreeningPatient ParticipationPilot ProjectsProgram EvaluationReagent Kits, DiagnosticSelf CareSerologic TestsSexual and Gender MinoritiesStandard of CareAnti-HIV AgentsReagent Kits, Diagnostic

Identifiers

PMID31971991
PMCPMC6977761
OpenAlexW3000984827

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.