ArticlePLoS pathogens2020
Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys.
Article in PLoS pathogens, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Article
- Guidance on Establishing Health Monitoring Panels for Laboratory Mice to Reflect Contemporary Pathogen Prevalence.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Review
- European Hedgehogs as Hosts of Chaphamaparvovirus, Italy.Animals : an open access journal from MDPI · 2024Article
- Article
- Prevalence and Pathologic Characterization of Mouse Kidney Parvovirus in Sentinel CD1 Mice.Comparative medicine · 2024Article
- Molecular epidemiological investigation and recombination analysis of Cachavirus prevalent in China.Frontiers in veterinary science · 2024Article
- Infectivity and Shedding of Mouse Kidney Parvovirus After Oronasal Inoculation of C57BL/6, CD1, and NSG Mice.Comparative medicine · 2022Article
- Comparative analysis reveals the long-term coevolutionary history of parvoviruses and vertebrates.PLoS biology · 2022Article
- Viral Biomarker Detection and Validation Using MALDI Mass Spectrometry Imaging (MSI).Proteomes · 2022Article
- Assessing Elimination of Mouse Kidney Parvovirus from Cages by Mechanical Washing.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- Chaphamaparvovirus antigen and nucleic acids are not detected in kidney tissues from cats with chronic renal disease or immunocompromised cats.Veterinary pathology · 2022Article
- Small but mighty: old and new parvoviruses of veterinary significance.Virology journal · 2021Review
- Triple SILAC identified progestin-independent and dependent PRA and PRB interacting partners in breast cancer.Scientific data · 2021Article
- Article
- Natural infection of parvovirus in wild fishing cats (Prionailurus viverrinus) reveals extant viral localization in kidneys.PloS one · 2021Article
- Identification of a new strain of mouse kidney parvovirus associated with inclusion body nephropathy in immunocompromised laboratory mice.Emerging microbes & infections · 2020Article
- Molecular detection and characterization of Carnivore chaphamaparvovirus 1 in dogs.Veterinary microbiology · 2020Article
- Article
- Going viral in the animal facility.Lab animal · 2020Article
- Virome of a Feline Outbreak of Diarrhea and Vomiting Includes Bocaviruses and a Novel Chapparvovirus.Viruses · 2020Article
Corrections and comments
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Authors and funding
19 authors at 11 institutions in 8 countries.
Funding
Abstract
Mouse kidney parvovirus (MKPV) is a member of the provisional genus Chapparvovirus that causes renal disease in immune-compromised mice, with a disease course reminiscent of polyomavirus-associated nephropathy in immune-suppressed kidney transplant patients. Here we map four major MKPV transcripts, created by alternative splicing, to a common initiator region, and use mass spectrometry to identify "p10" and "p15" as novel chapparvovirus accessory proteins produced in MKPV-infected kidneys. p15 and the splicing-dependent putative accessory protein NS2 are conserved in all near-complete amniote chapparvovirus genomes currently available (from mammals, birds and a reptile). In contrast, p10 may be encoded only by viruses with >60% amino acid identity to MKPV. We show that MKPV is kidney-tropic and that the bat chapparvovirus DrPV-1 and a non-human primate chapparvovirus, CKPV, are also found in the kidneys of their hosts. We propose, therefore, that many mammal chapparvoviruses are likely to be nephrotropic.
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