ArticleGut microbes2020
Antidepressant treatment with fluoxetine during pregnancy and lactation modulates the gut microbiome and metabolome in a rat model relevant to depression.
Article in Gut microbes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 56 citations in OpenAlex.
- The gut-brain axis in pharmacology: microbiome-driven modulation of CNS drugs and neuropsychiatric outcomes.Frontiers in pharmacology · 2026Review
- Perinatal citalopram exposure alters the gut composition and microbial metabolic profiles of Sprague-Dawley rat dams and female offspring but not male offspring.Biology of sex differences · 2025Article
- Dietary Fiber Modulates the Window of Susceptibility to Clostridioides difficile Infection.Gastroenterology · 2025Article
- Longitudinal metabolic profiling of women using selective serotonin reuptake inhibitors during pregnancy.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- The microbiome as a modulator of neurological health across the maternal-offspring interface.The Journal of clinical investigation · 2025Review
- The bidirectional interaction between antidepressants and the gut microbiota: are there implications for treatment response?International clinical psychopharmacology · 2025Review
- Does isovaleric acid play a key role in the interaction between probiotics and antidepressants? A secondary analysis of a randomized clinical trial.Computational and structural biotechnology journal · 2025Article
- Maternal SSRI Use During Pregnancy: Links Between Gut Microbiome, Offspring Behaviour, and Brain Transcriptomics.Current topics in behavioral neurosciences · 2025Review
- The role of natural products and traditional Chinese medicine formulas in postpartum depression: mechanism and prospects.Frontiers in pharmacology · 2025Review
- Gut microbiota as a novel target for treating anxiety and depression: from mechanisms to multimodal interventions.Frontiers in microbiology · 2025Review
- Pharmacological modulation of the gut-brain axis: psychobiotics in focus for depression therapy.Frontiers in pharmacology · 2025Review
- Investigating the influence of perinatal fluoxetine exposure on murine gut microbial communities during pregnancy and lactation.Scientific reports · 2024Article
- Mind, Mood and Microbiota-Gut-Brain Axis in Psychiatric Disorders.International journal of molecular sciences · 2024Review
- The Maternal Microbiome as a Map to Understanding the Impact of Prenatal Stress on Offspring Psychiatric Health.Biological psychiatry · 2024Review
- The causal association between gut microbiota and postpartum depression: a two-sample Mendelian randomization study.Frontiers in microbiology · 2024Article
- Selective serotonin reuptake inhibitors during pregnancy and lactation: A scoping review of effects on the maternal and infant gut microbiome.Developmental psychobiology · 2024Article
- Pharmacomicrobiomics of Antidepressants in Depression: A Systematic Review.Journal of personalized medicine · 2023Review
- Intestinal epithelial autophagy is required for the regenerative benefit of calorie restriction.American journal of physiology. Gastrointestinal and liver physiology · 2023Article
- The gut microbiome in social anxiety disorder: evidence of altered composition and function.Translational psychiatry · 2023Article
- The role of gut microbiota in depression: an analysis of the gut-brain axis.Frontiers in behavioral neuroscience · 2023Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Up to 10% of women use selective serotonin reuptake inhibitor (SSRI) antidepressants during pregnancy and postpartum. Recent evidence suggests that SSRIs are capable of altering the gut microbiota. However, the interaction between maternal depression and SSRI use on bacterial community composition and the availability of microbiota-derived metabolites during pregnancy and lactation is not clear. We studied this using a rat model relevant to depression, where adult females with a genetic vulnerability and stressed as pups show depressive-like behaviors. Throughout pregnancy and lactation, females received the SSRI fluoxetine or vehicle. High-resolution 16S ribosomal RNA marker gene sequencing and targeted metabolomic analysis were used to assess the fecal microbiome and metabolite availability, respectively. Not surprisingly, we found that pregnancy and lactation segregate in terms of fecal microbiome diversity and composition, accompanied by changes in metabolite availability. However, we also showed that fluoxetine treatment altered important features of this transition from pregnancy to lactation most clearly in previously stressed dams, with lower fecal amino acid concentrations. Amino acid concentrations, in turn, correlated negatively with the relative abundance of bacterial taxa such as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.