Evidence map›Paper›PMID 31971854›Full record

ArticleAutophagy2020

Mass spectrometry proteomics reveals a function for mammalian CALCOCO1 in MTOR-regulated selective autophagy.

Jonathan A Stefely, Yu Zhang, Elyse C Freiberger, Nicholas W Kwiecien, Hala Elnakat Thomas, Alexander M Davis, Nathaniel D Lowry, Catherine E Vincent, Evgenia Shishkova, Nicholas A Clark and 4 more

Open access · greenAbstract read
In one paragraph

Article in Autophagy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 53 citations in OpenAlex.

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  9. Visualizing ER-phagy and ER architecture in vivo.The Journal of cell biology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Jonathan A StefelyMorgridge Institute for Research , Madison, WI, USA.ORCID 0000-0003-3235-1107
Yu ZhangDivision of Hematology/Oncology, Department of Internal Medicine, University of Cincinnati , Cincinnati, OH, USA.
Elyse C FreibergerDepartment of Chemistry, University ofWisconsin-Madison , Madison, WI, USA.
Nicholas W KwiecienDepartment of Chemistry, University ofWisconsin-Madison , Madison, WI, USA.
Hala Elnakat ThomasDivision of Hematology/Oncology, Department of Internal Medicine, University of Cincinnati , Cincinnati, OH, USA.
Alexander M DavisDivision of Hematology/Oncology, Department of Internal Medicine, University of Cincinnati , Cincinnati, OH, USA.
Nathaniel D LowryDivision of Hematology/Oncology, Department of Internal Medicine, University of Cincinnati , Cincinnati, OH, USA.
Catherine E VincentGenome Center of Wisconsin , Madison, WI, USA.
Evgenia ShishkovaGenome Center of Wisconsin , Madison, WI, USA.ORCID 0000-0001-6097-6097
Nicholas A ClarkDivision of Biostatistics and Bioinformatics, Department of Environmental Health, University of Cincinnati , Cincinnati, OH, USA.ORCID 0000-0003-0105-9605
Mario MedvedovicDivision of Biostatistics and Bioinformatics, Department of Environmental Health, University of Cincinnati , Cincinnati, OH, USA.ORCID 0000-0003-4510-3102
Joshua J CoonMorgridge Institute for Research , Madison, WI, USA.ORCID 0000-0002-0004-8253
David J PagliariniMorgridge Institute for Research , Madison, WI, USA.ORCID 0000-0002-0001-0087
Carol A MercerDivision of Hematology/Oncology, Department of Internal Medicine, University of Cincinnati , Cincinnati, OH, USA.ORCID 0000-0002-7038-4690
University of Cincinnati · USUniversity of Wisconsin–Madison · USEnergy Center of Wisconsin · US

Funding

INTEGRATED TRAINING FOR PHYSICIAN-SCIENTISTST32GM008692 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BURKARD, MARK E · 1998 to 2020
$10.3M
Systems-to-structure approaches for defining mitochondrial protein functionR35GM131795 · NIGMS · WASHINGTON UNIVERSITY · PI David J Pagliarini · 2019 to 2026
$4.8M
NIGMS NIH HHS R35 GM131795NIGMS NIH HHS T32 GM008692
6 · The paper itself

Abstract

Macroautophagy/autophagy is suppressed by MTOR (mechanistic target of rapamycin kinase) and is an anticancer target under active investigation. Yet, MTOR-regulated autophagy remains incompletely mapped. We used proteomic profiling to identify proteins in the MTOR-autophagy axis. Wild-type (WT) mouse cell lines and cell lines lacking individual autophagy genes (

Indexed as

AutophagyMass SpectrometryProteomicsAmino Acid SequenceAnimalsCalcium-Binding ProteinsConserved SequenceEmbryo, MammalianFibroblastsHEK293 CellsHumansMammalsMCF-7 CellsMiceMicrotubule-Associated ProteinsProtein BindingCalcium-Binding ProteinsCalcoco1 protein, mouseMap1lc3b protein, mouseMicrotubule-Associated ProteinsTOR Serine-Threonine KinasesTranscription FactorsATG5CALCOCO1MAP1LC3mass spectrometry proteomicsMTORreticulophagyselective autophagyULK1ULK2

Identifiers

PMID31971854
PMCPMC7751563
OpenAlexW3000900895

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.