Evidence map›Paper›PMID 31971796›Full record

ArticleJournal of the American Society for Mass Spectrometry2020

Native vs Denatured: An in Depth Investigation of Charge State and Isotope Distributions.

Jared O Kafader, Rafael D Melani, Luis F Schachner, Ashley N Ives, Steven M Patrie, Neil L Kelleher, Philip D Compton

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Society for Mass Spectrometry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. Article
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  4. Response Factor Correction for Quantitative Determination of HomooligomericJournal of the American Society for Mass Spectrometry · 2026
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  6. Review
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  9. Review
  10. Intact Mass Proteomics Using a Proteoform Atlas.Journal of proteome research · 2025
    Article
  11. Article
  12. Review
  13. Single Cell Analysis of Proteoforms.Journal of proteome research · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jared O KafaderDepartments of Chemistry and Molecular Biosciences, Chemistry of Life Processes Institute, Proteomics Center of Excellence at Northwestern University, Evanston, Illinois 60208, United States.ORCID http://orcid.org/0000-0002-5359-264X
Rafael D MelaniDepartments of Chemistry and Molecular Biosciences, Chemistry of Life Processes Institute, Proteomics Center of Excellence at Northwestern University, Evanston, Illinois 60208, United States.
Luis F SchachnerDepartments of Chemistry and Molecular Biosciences, Chemistry of Life Processes Institute, Proteomics Center of Excellence at Northwestern University, Evanston, Illinois 60208, United States.
Ashley N IvesDepartments of Chemistry and Molecular Biosciences, Chemistry of Life Processes Institute, Proteomics Center of Excellence at Northwestern University, Evanston, Illinois 60208, United States.
Steven M PatrieDepartments of Chemistry and Molecular Biosciences, Chemistry of Life Processes Institute, Proteomics Center of Excellence at Northwestern University, Evanston, Illinois 60208, United States.ORCID http://orcid.org/0000-0002-0308-5498
Neil L KelleherDepartments of Chemistry and Molecular Biosciences, Chemistry of Life Processes Institute, Proteomics Center of Excellence at Northwestern University, Evanston, Illinois 60208, United States.ORCID http://orcid.org/0000-0002-8815-3372
Philip D ComptonDepartments of Chemistry and Molecular Biosciences, Chemistry of Life Processes Institute, Proteomics Center of Excellence at Northwestern University, Evanston, Illinois 60208, United States.ORCID http://orcid.org/0000-0001-5212-7175
Northwestern University · US

Funding

Chemistry of Life Processes Predoctoral Training ProgramT32GM105538 · NIGMS · NORTHWESTERN UNIVERSITY · PI KELLEHER, NEIL L · 2013 to 2022
$2.7M
NIGMS NIH HHS T32 GM105538
6 · The paper itself

Abstract

New tools and techniques have dramatically accelerated the field of structural biology over the past several decades. One potent and relatively new technique that is now being utilized by an increasing number of laboratories is the combination of so-called "native" electrospray ionization (ESI) with mass spectrometry (MS) for the characterization of proteins and their noncovalent complexes. However, native ESI-MS produces species at increasingly higher

Indexed as

AnimalsHumansIonsProtein DenaturationProteinsSpectrometry, Mass, Electrospray IonizationStatic ElectricityIonsProteins

Identifiers

PMID31971796
PMCPMC7539638
OpenAlexW3005204542

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.