Evidence map›Paper›PMID 31971772›Full record

ArticleACS nano2020

Tuning Nanoparticle Interactions with Ovarian Cancer through Layer-by-Layer Modification of Surface Chemistry.

Santiago Correa, Natalie Boehnke, Antonio E Barberio, Elad Deiss-Yehiely, Aria Shi, Benjamin Oberlton, Sean G Smith, Ioannis Zervantonakis, Erik C Dreaden, Paula T Hammond

Open access · greenAbstract read
In one paragraph

Article in ACS nano, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 107 citations in OpenAlex.

  1. Eco-Friendly Synthesis of Silver Nanoparticles UsingInternational journal of molecular sciences · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Pooled Nanoparticle Screening Using a Chemical Barcoding Approach.Angewandte Chemie (International ed. in English) · 2025
    Article
  18. Article
  19. Charge-Stabilized Nanodiscs as a New Class of Lipid Nanoparticles.Advanced materials (Deerfield Beach, Fla.) · 2024
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Santiago CorreaDepartment of Biological Engineering , Massachusetts Institute of Technology , 21 Ames Street , Cambridge , Massachusetts 02142 , United States.
Natalie BoehnkeKoch Institute for Integrative Cancer Research , Massachusetts Institute of Technology , 500 Main Street , Cambridge , Massachusetts 02142 , United States.ORCID 0000-0002-3468-2033
Antonio E BarberioDepartment of Chemical Engineering , Massachusetts Institute of Technology , 25 Ames Street , Cambridge , Massachusetts 02142 , United States.
Elad Deiss-YehielyDepartment of Materials Science and Engineering , Massachusetts Institute of Technology , 183 Memorial Drive , Cambridge , Massachusetts 02142 , United States.ORCID 0000-0002-4345-7903
Aria ShiDepartment of Biological Engineering , Massachusetts Institute of Technology , 21 Ames Street , Cambridge , Massachusetts 02142 , United States.ORCID 0000-0002-0695-7124
Benjamin OberltonDepartment of Biological Engineering , Massachusetts Institute of Technology , 21 Ames Street , Cambridge , Massachusetts 02142 , United States.
Sean G SmithKoch Institute for Integrative Cancer Research , Massachusetts Institute of Technology , 500 Main Street , Cambridge , Massachusetts 02142 , United States.
Ioannis ZervantonakisDepartment of Cell Biology, Ludwig Center at Harvard , Harvard Medical School , Boston , Massachusetts 02115 , United States.
Erik C DreadenKoch Institute for Integrative Cancer Research , Massachusetts Institute of Technology , 500 Main Street , Cambridge , Massachusetts 02142 , United States.
Paula T HammondKoch Institute for Integrative Cancer Research , Massachusetts Institute of Technology , 500 Main Street , Cambridge , Massachusetts 02142 , United States.ORCID 0000-0002-9835-192X
Massachusetts Institute of Technology · USHarvard University · USInstitute for Soldier Nanotechnologies · US

Funding

VIRUS PRODUCTION COREP30CA014051 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Jacqueline A. Lees · 1985 to 2026
$93.9M
Interdepartmental Biotechnology Training ProgramT32GM008334 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI WITTRUP, KARL DANE · 1989 to 2018
$15.2M
Identifying and targeting evolutionary trajectories in cancerR01CA233477 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI HEMANN, MICHAEL · 2019 to 2023
$1.7M
LbL Nanotechnologies for Synergistic Therapy of Advanced Ovarian CarcinomaF32EB017614 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI DREADEN, ERIK CHRISTOPHER · 2013 to 2014
$102k
NCI NIH HHS P30 CA014051NCI NIH HHS R01 CA233477NIBIB NIH HHS F32 EB017614NIGMS NIH HHS T32 GM008334
6 · The paper itself

Abstract

Nanoparticle surface chemistry is a fundamental engineering parameter that governs tumor-targeting activity. Electrostatic assembly generates controlled polyelectrolyte complexes through the process of adsorption and charge overcompensation utilizing synthetic polyions and natural biomacromolecules; it can yield films with distinctive hydration, charge, and presentation of functional groups. Here, we used electrostatic layer-by-layer (LbL) assembly to screen 10 different surface chemistries for their ability to preferentially target human ovarian cancer

Indexed as

Cell Line, TumorFemaleHumansHyaluronic AcidNanoparticlesOvarian NeoplasmsParticle SizePeptidesPolyglutamic AcidStatic ElectricitySurface PropertiesHyaluronic AcidPeptidespolyaspartatePolyglutamic Acidlayer-by-layernanomedicinenanoparticlesovarian cancersubcellular targetingsurface chemistrytumor-targeting

Identifiers

PMID31971772
PMCPMC7062411
OpenAlexW3002758941

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.