ArticleAmerican journal of epidemiology2020
An Innovative, Prospective, Hybrid Cohort-Cluster Study Design to Characterize Dengue Virus Transmission in Multigenerational Households in Kamphaeng Phet, Thailand.
Article in American journal of epidemiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Development and optimization of self-collected, field stable, saliva-based immunoassays for scalable epidemiological surveillance of pathogen-specific immunity.medRxiv : the preprint server for health sciences · 2026Article
- Zika Virus Neutralizing Antibody Responses Elicited by Vaccination or Infection.Open forum infectious diseases · 2025Article
- Linking multiple serological assays to infer dengue virus infections from paired samples using mixture models.PLoS computational biology · 2025Article
- Antibody response to Aedes aegypti D7L1 + 2 salivary proteins as marker of aggregate vector exposure and correlate of dengue virus susceptibility.PLoS neglected tropical diseases · 2025Article
- Force of Infection Model for Estimating Time to Dengue Virus Seropositivity among Expatriate Populations, Thailand.Emerging infectious diseases · 2025Article
- Proceedings of the second annual dengue endgame summit: A call to action.PLoS neglected tropical diseases · 2025Article
- Reconciling heterogeneous dengue virus infection risk estimates from different study designs.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Reconciling heterogeneous dengue virus infection risk estimates from different study designs.medRxiv : the preprint server for health sciences · 2024Article
- Integration of population-level data sources into an individual-level clinical prediction model for dengue virus test positivity.Science advances · 2024Article
- Household immunity and individual risk of infection with dengue virus in a prospective, longitudinal cohort study.Nature microbiology · 2024Article
- Advancing pathogen genomics in resource-limited settings.Cell genomics · 2023Review
- Maternally derived antibody titer dynamics and risk of hospitalized infant dengue disease.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Individual, Household, and Community Drivers of Dengue Virus Infection Risk in Kamphaeng Phet Province, Thailand.The Journal of infectious diseases · 2022Article
- World Dengue Day: A call for action.PLoS neglected tropical diseases · 2022Article
- RE: ``AN INNOVATIVE, PROSPECTIVE, HYBRID COHORT-CLUSTER STUDY DESIGN TO CHARACTERIZE DENGUE VIRUS TRANSMISSION IN MULTIGENERATIONAL HOUSEHOLDS IN KAMPHAENG PHET, THAILAND''.American journal of epidemiology · 2021Article
- Correlation between reported dengue illness history and seropositivity in rural Thailand.PLoS neglected tropical diseases · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
17 authors.
Funding
Abstract
Difficulties inherent in the identification of immune correlates of protection or severe disease have challenged the development and evaluation of dengue vaccines. There persist substantial gaps in knowledge about the complex effects of age and sequential dengue virus (DENV) exposures on these correlations. To address these gaps, we were conducting a novel family-based cohort-cluster study for DENV transmission in Kamphaeng Phet, Thailand. The study began in 2015 and is funded until at least 2023. As of May 2019, 2,870 individuals in 485 families were actively enrolled. The families comprise at least 1 child born into the study as a newborn, 1 other child, a parent, and a grandparent. The median age of enrolled participants is 21 years (range 0-93 years). Active surveillance is performed to detect acute dengue illnesses, and annual blood testing identifies subclinical seroconversions. Extended follow-up of this cohort will detect sequential infections and correlate antibody kinetics and sequence of infections with disease outcomes. The central goal of this prospective study is to characterize how different DENV exposure histories within multigenerational family units, from DENV-naive infants to grandparents with multiple prior DENV exposures, affect transmission, disease, and protection at the level of the individual, household, and community.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.