ArticleeLife2020
C1 neurons are part of the circuitry that recruits active expiration in response to the activation of peripheral chemoreceptors.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Molecular changes in hypoxia-induced central neural circuits and nuclei.Medical gas research · 2026Review
- Article
- Functional modulation of retrotrapezoid neurons drives fentanyl-induced respiratory depression.American journal of physiology. Lung cellular and molecular physiology · 2025Article
- Neuroanatomical and neurochemical organization of brainstem and forebrain circuits involved in breathing regulation.Journal of neurophysiology · 2025Review
- Modelling a pathological GSX2 variant that selectively alters DNA binding reveals hypomorphic mouse brain defects.Disease models & mechanisms · 2025Article
- Article
- Adrenergic C1 neurons enhance anxiety via projections to PAG.bioRxiv : the preprint server for biology · 2024Article
- SubSol-HIe is an AMPK-dependent hypoxia-responsive subnucleus of the nucleus tractus solitarius that coordinates the hypoxic ventilatory response and protects against apnoea in mice.Pflugers Archiv : European journal of physiology · 2024Article
- Article
- The Rostral Ventromedial and Lateral Medulla Are the Major Areas Responsive to Lung Cancer Progression among Brainstem Lung-Innervating Nuclei.Brain sciences · 2022Article
- Analyzing the brainstem circuits for respiratory chemosensitivity in freely moving mice.eLife · 2022Article
- Breathing Rhythm and Pattern and Their Influence on Emotion.Annual review of neuroscience · 2022Review
- Histamine/H1 receptor signaling in the parafacial region increases activity of chemosensitive neurons and respiratory activity in rats.Journal of neurophysiology · 2022Article
- The influence of mouth opening on pharyngeal pressure loss and its underlying mechanism: A computational fluid dynamic analysis.Frontiers in bioengineering and biotechnology · 2022Article
- The carotid body: A novel key player in neuroimmune interactions.Frontiers in immunology · 2022Review
- Differential Contribution of the Retrotrapezoid Nucleus and C1 Neurons to Active Expiration and Arousal in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Differential modulation of active expiration during hypercapnia by the medullary raphe in unanesthetized rats.Pflugers Archiv : European journal of physiology · 2020Article
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Authors and funding
5 authors.
Funding
Abstract
Breathing results from the interaction of two distinct oscillators: the pre-Bötzinger Complex (preBötC), which drives inspiration; and the lateral parafacial region (pFRG), which drives active expiration. The pFRG is silent at rest and becomes rhythmically active during the stimulation of peripheral chemoreceptors, which also activates adrenergic C1 cells. We postulated that the C1 cells and the pFRG may constitute functionally distinct but interacting populations for controlling expiratory activity during hypoxia. We found in rats that: a) C1 neurons are activated by hypoxia and project to the pFRG region; b) active expiration elicited by hypoxia was blunted after blockade of ionotropic glutamatergic receptors at the level of the pFRG; and c) selective depletion of C1 neurons eliminated the active expiration elicited by hypoxia. These results suggest that C1 cells may regulate the respiratory cycle, including active expiration, under hypoxic conditions.
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