ArticleCell and tissue research1988
A combined histochemical and immunohistochemical study on the dynamics of fast-to-slow fiber transformation in chronically stimulated rabbit muscle.
Article in Cell and tissue research, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 75 citations in OpenAlex.
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- Assessment of muscle mass and strength in mice.BoneKEy reports · 2015Article
- Developmental myosins: expression patterns and functional significance.Skeletal muscle · 2015Article
- Chronic low-frequency stimulation transforms cat masticatory muscle fibers into jaw-slow fibers.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2011Article
- Partial fast-to-slow conversion of regenerating rat fast-twitch muscle by chronic low-frequency stimulation.Journal of muscle research and cell motility · 2002Article
- Effect of tibial bone resection on the development of fast- and slow-twitch skeletal muscles in foetal sheep.Journal of muscle research and cell motility · 2000Article
- Transient expression of myosin heavy chain MHCI alpha in rabbit muscle during fast-to-slow transition.Journal of muscle research and cell motility · 1999Article
- Expression of an alpha-cardiac like myosin heavy chain in diaphragm, chronically stimulated, and denervated fast-twitch muscles of rabbit.Journal of muscle research and cell motility · 1997Article
- Induction of molecular and mechanical transformations in canine skeletal muscle by chronic neuromuscular stimulation.Journal of muscle research and cell motility · 1997Article
- Contractile properties and myosin heavy chain composition of newborn rat soleus muscles at different stages of postnatal development.Journal of muscle research and cell motility · 1997Article
- Intermediate filament proteins increase during chronic stimulation of skeletal muscle.Journal of muscle research and cell motility · 1995Article
- The response of adult and developing rat plantaris muscle to overload.Pflugers Archiv : European journal of physiology · 1995Article
- Fibre composition of rabbit tibialis anterior and extensor digitorum longus muscles.Journal of anatomy · 1995Article
- Analysis of Ca2+ and Sr2+ activation characteristics in skinned muscle fibre preparations with different proportions of myofibrillar isoforms.Journal of muscle research and cell motility · 1995Article
- Morphological changes during fiber type transitions in low-frequency-stimulated rat fast-twitch muscle.Cell and tissue research · 1994Article
- Asynchronous increases in oxidative capacity and resistance to fatigue of electrostimulated muscles of rat and rabbit.The Journal of physiology · 1993Article
- Mammalian skeletal muscle fibers distinguished by contents of phosphocreatine, ATP, and Pi.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Quantitative morphology of stimulation-induced damage in rabbit fast-twitch skeletal muscles.Cell and tissue research · 1992Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronically stimulated fast-twitch muscles of the rabbit were histochemically and immunohistochemically analyzed in serial cross sections (1) for percentages of fiber types, and (2) for the presence of myosin heavy chain isoforms during fast-to-slow transformation. By four weeks of stimulation the number of type-I fibers had increased more than fourfold, while only about 6% of the original IIB fibers remained. Type-IC and -IIC fibers transiently rose to 20% of the total fiber population. After 16 weeks, the number of type-I fibers had increased to 42%. With prolonged stimulation fewer fibers reacted with antibodies against embryonic and neonatal myosins and more with the antibody against slow myosin. The reaction for embryonic myosin was most often detected in the C fibers (IC, IIC). Immunohistochemical subtypes were observed for each fiber type in the stimulated muscles. The greatest number was seen in type-IIC fibers, which, in addition to their reaction for fast/neonatal and slow myosins, might also react with the antibodies against neonatal/embryonic and embryonic myosins. These findings indicated that the transforming fibers temporarily expressed myosin heavy chain isoforms normally not detectable in adult skeletal muscle. Myotubes reacted strongly with the antibodies against fast/neonatal and embryonic myosins, and some of them also with the antibody against slow myosin. Thus, it appears that under the influence of the low frequency stimulus pattern some of the newly formed myotubes developed into type-I fibers.
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