ArticleTissue engineering and regenerative medicine2020
Oral Soft Tissue Regeneration Using Nano Controlled System Inducing Sequential Release of Trichloroacetic Acid and Epidermal Growth Factor.
Article in Tissue engineering and regenerative medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Potential of Trichloroacetic Acid in Smear Layer and Calcium Hydroxide Removal in Root Canals-Exploratory Pilot Studies In Vitro.International dental journal · 2026Article
- Evaluation of biological functionality of biomaterial surface modified by advanced laser equipment.Journal of materials science. Materials in medicine · 2025Article
- Effect of chitosan and chlorhexidine on demineraslised dentin to enhance adhesion.Bioinformation · 2025Article
- Glycan-based scaffolds and nanoparticles as drug delivery system in cancer therapy.Frontiers in immunology · 2024Review
- Advanced materials and technologies for oral diseases.Science and technology of advanced materials · 2023Review
- Understanding Scarring in the Oral Mucosa.Advances in wound care · 2022Review
- Chitosan-induced biomodification on demineralized dentin to improve the adhesive interface.Restorative dentistry & endodontics · 2022Article
- The Application of Chitosan Nanostructures in Stomatology.Molecules (Basel, Switzerland) · 2021Review
- Innovative Molecular and Cellular Therapeutics in Cleft Palate Tissue Engineering.Tissue engineering. Part B, Reviews · 2021Review
- Polysaccharide-Based Materials Created by Physical Processes: From Preparation to Biomedical Applications.Pharmaceutics · 2021Review
- Association between the microbiomes of tonsil and saliva samples isolated from pediatric patients subjected to tonsillectomy for the treatment of tonsillar hyperplasia.Experimental & molecular medicine · 2020Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe effect of nano controlled sequential release of trichloroacetic acid (TCA) and epidermal growth factor (EGF) on the oral soft tissue regeneration was determined.
methodsHydrophobically modified glycol chitosan (HGC) nano controlled system was developed for the sequential release of TCA and EGF, and the release pattern was identified. The HGC-based nano controlled release system was injected into the critical-sized defects created in beagles' palatal soft tissues. The palatal impression and its scanned body was obtained on various time points post-injection, and the volumetric amount of soft tissue regeneration was compared among the three groups: CON (natural regeneration control group), EXP1 (TCA-loaded nano controlled release system group), EXP2 (TCA and EGF individually loaded nano controlled release system). DNA microarray analysis was performed and various soft tissue regeneration parameters in histopathological specimens were measured.
resultsTCA release was highest at Day 1 whereas EGF release was highest at Day 2 and remained high until Day 3. In the volumetric measurements of impression body scans, no significant difference in soft tissue regeneration between the three groups was shown in two-way ANOVA. However, in the one-way ANOVA at Day 14, EXP2 showed a significant increase in soft tissue regeneration compared to CON. High correlation was determined between the histopathological results of each group. DNA microarray showed up-regulation of various genes and related cell signaling pathways in EXP2 compared to CON.
conclusionHGC-based nano controlled release system for sequential release of TCA and EGF can promote regeneration of oral soft tissue defects.
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Registered trials
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